Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure

Significance The plasma membrane of cardiac myocytes contains complex invaginations known as transverse tubules (T-tubules). In heart failure, T-tubule loss is a major contributor to Ca ²⁺ transient abnormalities, leading to weaker and slower contraction. Current therapeutic strategies are often bas...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (42), p.15196-15201
Hauptverfasser: Crocini, Claudia, Coppini, Raffaele, Ferrantini, Cecilia, Yan, Ping, Loew, Leslie M., Tesi, Chiara, Cerbai, Elisabetta, Poggesi, Corrado, Pavone, Francesco S., Sacconi, Leonardo
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Sprache:eng
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