Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein

Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the...

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Veröffentlicht in:Circulation Journal 2014/10/24, Vol.78(11), pp.2682-2687
Hauptverfasser: Takashima, Akira, Ise, Takayuki, Yagi, Shusuke, Iwase, Takashi, Kimura, Sahika, Ueda, Yuka, Nishikawa, Koji, Ishii, Ayumi, Niki, Toshiyuki, Yamaguchi, Koji, Taketani, Yoshio, Yamada, Hirotsugu, Soeki, Takeshi, Wakatsuki, Tetsuzo, Katoh, Shinsuke, Akaike, Masashi, Sata, Masataka
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Sprache:eng
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Zusammenfassung:Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.Methods and Results:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (V̇O2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak V̇O2increased significantly in the CR group (P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-14-0532