Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein
Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the...
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| Veröffentlicht in: | Circulation Journal 2014/10/24, Vol.78(11), pp.2682-2687 |
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| creator | Takashima, Akira Ise, Takayuki Yagi, Shusuke Iwase, Takashi Kimura, Sahika Ueda, Yuka Nishikawa, Koji Ishii, Ayumi Niki, Toshiyuki Yamaguchi, Koji Taketani, Yoshio Yamada, Hirotsugu Soeki, Takeshi Wakatsuki, Tetsuzo Katoh, Shinsuke Akaike, Masashi Sata, Masataka |
| description | Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.Methods and Results:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (V̇O2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak V̇O2increased significantly in the CR group (P |
| doi_str_mv | 10.1253/circj.CJ-14-0532 |
| format | Article |
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However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.Methods and Results:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (V̇O2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak V̇O2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. ∆V̇O2(peak V̇O2after CR–peak V̇O2before CR) was negatively associated with ∆MDA-LDL (MDA-LDL after CR–MDA-LDL before CR) (R2=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.Conclusions:CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682–2687)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-14-0532</identifier><identifier>PMID: 25241889</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Cardiac Rehabilitation ; Cardiovascular Diseases - blood ; Female ; Follow-Up Studies ; Humans ; Lipoproteins ; Lipoproteins, LDL - blood ; Male ; Malondialdehyde - blood ; Middle Aged ; Oxidative stress</subject><ispartof>Circulation Journal, 2014/10/24, Vol.78(11), pp.2682-2687</ispartof><rights>2014 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c652t-5d26306e4594ca9f1b5a71a9a57ae987c6ec20ed67ded3bfb42e2a31d13755673</citedby><cites>FETCH-LOGICAL-c652t-5d26306e4594ca9f1b5a71a9a57ae987c6ec20ed67ded3bfb42e2a31d13755673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25241889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takashima, Akira</creatorcontrib><creatorcontrib>Ise, Takayuki</creatorcontrib><creatorcontrib>Yagi, Shusuke</creatorcontrib><creatorcontrib>Iwase, Takashi</creatorcontrib><creatorcontrib>Kimura, Sahika</creatorcontrib><creatorcontrib>Ueda, Yuka</creatorcontrib><creatorcontrib>Nishikawa, Koji</creatorcontrib><creatorcontrib>Ishii, Ayumi</creatorcontrib><creatorcontrib>Niki, Toshiyuki</creatorcontrib><creatorcontrib>Yamaguchi, Koji</creatorcontrib><creatorcontrib>Taketani, Yoshio</creatorcontrib><creatorcontrib>Yamada, Hirotsugu</creatorcontrib><creatorcontrib>Soeki, Takeshi</creatorcontrib><creatorcontrib>Wakatsuki, Tetsuzo</creatorcontrib><creatorcontrib>Katoh, Shinsuke</creatorcontrib><creatorcontrib>Akaike, Masashi</creatorcontrib><creatorcontrib>Sata, Masataka</creatorcontrib><title>Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.Methods and Results:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (V̇O2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak V̇O2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. ∆V̇O2(peak V̇O2after CR–peak V̇O2before CR) was negatively associated with ∆MDA-LDL (MDA-LDL after CR–MDA-LDL before CR) (R2=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.Conclusions:CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682–2687)</description><subject>Aged</subject><subject>Cardiac Rehabilitation</subject><subject>Cardiovascular Diseases - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lipoproteins</subject><subject>Lipoproteins, LDL - blood</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Oxidative stress</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAQRi0EYincOaEcuQS8Jz6isCtSJZaz5dgTcJUmxU7Yfj0pLfQyi_TmG-khdEzwGaGCnVsf7OysuE8JT7FgdAvtE8azlOcUb__OMlU5Z3voIMYZxlRhoXbRHhWUkzxX-2hamOC8sckDvJrKN743ve_acXWDhZg8QhjmSQnv0MSkq5Ppp3f-G1xSdh_pJbTR919J6RfdInQ9-PYQ7dSmiXC07hP0fH31VNym5fTmrrgoUysF7VPhqGRYAheKW6NqUgmTEaOMyAyoPLMSLMXgZObAsaquOAVqGHGEZULIjE3Q6Sp3_Ps2QOz13EcLTWNa6IaoiSRytMCkGlG8Qm3oYgxQ60XwcxO-NMF6qVH_atTFvSZcLzWOJyfr9KGag_s_-PM2AjcrYBZ78wL_gAm9tw2sE7NcE7Ksm-gN8WqChpb9AHDAiMw</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Takashima, Akira</creator><creator>Ise, Takayuki</creator><creator>Yagi, Shusuke</creator><creator>Iwase, Takashi</creator><creator>Kimura, Sahika</creator><creator>Ueda, Yuka</creator><creator>Nishikawa, Koji</creator><creator>Ishii, Ayumi</creator><creator>Niki, Toshiyuki</creator><creator>Yamaguchi, Koji</creator><creator>Taketani, Yoshio</creator><creator>Yamada, Hirotsugu</creator><creator>Soeki, Takeshi</creator><creator>Wakatsuki, Tetsuzo</creator><creator>Katoh, Shinsuke</creator><creator>Akaike, Masashi</creator><creator>Sata, Masataka</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein</title><author>Takashima, Akira ; Ise, Takayuki ; Yagi, Shusuke ; Iwase, Takashi ; Kimura, Sahika ; Ueda, Yuka ; Nishikawa, Koji ; Ishii, Ayumi ; Niki, Toshiyuki ; Yamaguchi, Koji ; Taketani, Yoshio ; Yamada, Hirotsugu ; Soeki, Takeshi ; Wakatsuki, Tetsuzo ; Katoh, Shinsuke ; Akaike, Masashi ; Sata, Masataka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c652t-5d26306e4594ca9f1b5a71a9a57ae987c6ec20ed67ded3bfb42e2a31d13755673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Cardiac Rehabilitation</topic><topic>Cardiovascular Diseases - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lipoproteins</topic><topic>Lipoproteins, LDL - blood</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Oxidative stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takashima, Akira</creatorcontrib><creatorcontrib>Ise, Takayuki</creatorcontrib><creatorcontrib>Yagi, Shusuke</creatorcontrib><creatorcontrib>Iwase, Takashi</creatorcontrib><creatorcontrib>Kimura, Sahika</creatorcontrib><creatorcontrib>Ueda, Yuka</creatorcontrib><creatorcontrib>Nishikawa, Koji</creatorcontrib><creatorcontrib>Ishii, Ayumi</creatorcontrib><creatorcontrib>Niki, Toshiyuki</creatorcontrib><creatorcontrib>Yamaguchi, Koji</creatorcontrib><creatorcontrib>Taketani, Yoshio</creatorcontrib><creatorcontrib>Yamada, Hirotsugu</creatorcontrib><creatorcontrib>Soeki, Takeshi</creatorcontrib><creatorcontrib>Wakatsuki, Tetsuzo</creatorcontrib><creatorcontrib>Katoh, Shinsuke</creatorcontrib><creatorcontrib>Akaike, Masashi</creatorcontrib><creatorcontrib>Sata, Masataka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takashima, Akira</au><au>Ise, Takayuki</au><au>Yagi, Shusuke</au><au>Iwase, Takashi</au><au>Kimura, Sahika</au><au>Ueda, Yuka</au><au>Nishikawa, Koji</au><au>Ishii, Ayumi</au><au>Niki, Toshiyuki</au><au>Yamaguchi, Koji</au><au>Taketani, Yoshio</au><au>Yamada, Hirotsugu</au><au>Soeki, Takeshi</au><au>Wakatsuki, Tetsuzo</au><au>Katoh, Shinsuke</au><au>Akaike, Masashi</au><au>Sata, Masataka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2014</date><risdate>2014</risdate><volume>78</volume><issue>11</issue><spage>2682</spage><epage>2687</epage><pages>2682-2687</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.Methods and Results:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (V̇O2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak V̇O2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. ∆V̇O2(peak V̇O2after CR–peak V̇O2before CR) was negatively associated with ∆MDA-LDL (MDA-LDL after CR–MDA-LDL before CR) (R2=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.Conclusions:CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682–2687)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>25241889</pmid><doi>10.1253/circj.CJ-14-0532</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Cardiac Rehabilitation Cardiovascular Diseases - blood Female Follow-Up Studies Humans Lipoproteins Lipoproteins, LDL - blood Male Malondialdehyde - blood Middle Aged Oxidative stress |
| title | Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein |
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