Effect of carbonic anhydrase inhibitors on Anopheles albimanus larvae (Diptera: Culicidae)

Carbonic anhydrase (CA) catalyzes the reversible conversion of CO2 to bicarbonate and participates in mechanisms of alkalinization in the intestine of mosquitoes. The toxicity of four CA inhibitors (CAI ): acetazolamide (AZ M), methazolamide (MZM), ethoxolamide (ETX) and dorzolamide (DZA ) were eval...

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Veröffentlicht in:Revista colombiana de entomología 2013-07, Vol.39 (2), p.226-228
Hauptverfasser: Rocha, Leonardo O, Torres, Carolina G, Corena-McLeod, Maria, Velez, Ivan D B, Robledo, Sara M R
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Sprache:spa
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Zusammenfassung:Carbonic anhydrase (CA) catalyzes the reversible conversion of CO2 to bicarbonate and participates in mechanisms of alkalinization in the intestine of mosquitoes. The toxicity of four CA inhibitors (CAI ): acetazolamide (AZ M), methazolamide (MZM), ethoxolamide (ETX) and dorzolamide (DZA ) were evaluated in larvae of Anopheles albimanus by monitoring mortality 24, 48 and 72 hours post application, at a concentration of 50 ug/ml diluted in dimethyl sulfoxide previously. All IA C reduced the population of larvae in variable proportions. ETX showed the highest toxicity, achieving more than 80% mortality after 24 hours and 98% after 72 hours of application. The CAI , AZ M, MZM and DZA showed less toxicity (
ISSN:0120-0488
2665-4385
DOI:10.25100/socolen.v39i2.8240