Effect of carbonic anhydrase inhibitors on Anopheles albimanus larvae (Diptera: Culicidae)
Carbonic anhydrase (CA) catalyzes the reversible conversion of CO2 to bicarbonate and participates in mechanisms of alkalinization in the intestine of mosquitoes. The toxicity of four CA inhibitors (CAI ): acetazolamide (AZ M), methazolamide (MZM), ethoxolamide (ETX) and dorzolamide (DZA ) were eval...
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| Veröffentlicht in: | Revista colombiana de entomología 2013-07, Vol.39 (2), p.226-228 |
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| container_title | Revista colombiana de entomología |
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| creator | Rocha, Leonardo O Torres, Carolina G Corena-McLeod, Maria Velez, Ivan D B Robledo, Sara M R |
| description | Carbonic anhydrase (CA) catalyzes the reversible conversion of CO2 to bicarbonate and participates in mechanisms of alkalinization in the intestine of mosquitoes. The toxicity of four CA inhibitors (CAI ): acetazolamide (AZ M), methazolamide (MZM), ethoxolamide (ETX) and dorzolamide (DZA ) were evaluated in larvae of Anopheles albimanus by monitoring mortality 24, 48 and 72 hours post application, at a concentration of 50 ug/ml diluted in dimethyl sulfoxide previously. All IA C reduced the population of larvae in variable proportions. ETX showed the highest toxicity, achieving more than 80% mortality after 24 hours and 98% after 72 hours of application. The CAI , AZ M, MZM and DZA showed less toxicity ( |
| doi_str_mv | 10.25100/socolen.v39i2.8240 |
| format | Article |
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The toxicity of four CA inhibitors (CAI ): acetazolamide (AZ M), methazolamide (MZM), ethoxolamide (ETX) and dorzolamide (DZA ) were evaluated in larvae of Anopheles albimanus by monitoring mortality 24, 48 and 72 hours post application, at a concentration of 50 ug/ml diluted in dimethyl sulfoxide previously. All IA C reduced the population of larvae in variable proportions. ETX showed the highest toxicity, achieving more than 80% mortality after 24 hours and 98% after 72 hours of application. The CAI , AZ M, MZM and DZA showed less toxicity (<50% mortality). 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anopheles albimanus Culicidae Diptera |
| title | Effect of carbonic anhydrase inhibitors on Anopheles albimanus larvae (Diptera: Culicidae) |
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