Association of serum cytokines levels, interleukin 10 −1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia

•Levels of IL-4 and IL-13 were significantly higher in atopic asthmatics.•IFN-γ levels were significantly lower in patients than controls.•No significant difference in IL-10 levels between atopic asthma and controls.•Significant association of IL-10 and IFN-γ SNPs with atopic asthma.•IFN-γ +874T/A g...

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Veröffentlicht in:Cellular immunology 2014-05, Vol.289 (1-2), p.21-26
Hauptverfasser: Hussein, Y.M., Alzahrani, S.S., Alharthi, A.A., Ghonaim, M.M., Alhazmi, A.S., Eed, E.M., Shalaby, S.M.
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Sprache:eng
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Zusammenfassung:•Levels of IL-4 and IL-13 were significantly higher in atopic asthmatics.•IFN-γ levels were significantly lower in patients than controls.•No significant difference in IL-10 levels between atopic asthma and controls.•Significant association of IL-10 and IFN-γ SNPs with atopic asthma.•IFN-γ +874T/A gene polymorphism was associated with decreased IFN-γ levels. The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 −1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p
ISSN:0008-8749
1090-2163
DOI:10.1016/j.cellimm.2014.03.006