Association of serum cytokines levels, interleukin 10 −1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia
•Levels of IL-4 and IL-13 were significantly higher in atopic asthmatics.•IFN-γ levels were significantly lower in patients than controls.•No significant difference in IL-10 levels between atopic asthma and controls.•Significant association of IL-10 and IFN-γ SNPs with atopic asthma.•IFN-γ +874T/A g...
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| Veröffentlicht in: | Cellular immunology 2014-05, Vol.289 (1-2), p.21-26 |
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| container_title | Cellular immunology |
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| creator | Hussein, Y.M. Alzahrani, S.S. Alharthi, A.A. Ghonaim, M.M. Alhazmi, A.S. Eed, E.M. Shalaby, S.M. |
| description | •Levels of IL-4 and IL-13 were significantly higher in atopic asthmatics.•IFN-γ levels were significantly lower in patients than controls.•No significant difference in IL-10 levels between atopic asthma and controls.•Significant association of IL-10 and IFN-γ SNPs with atopic asthma.•IFN-γ +874T/A gene polymorphism was associated with decreased IFN-γ levels.
The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 −1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p |
| doi_str_mv | 10.1016/j.cellimm.2014.03.006 |
| format | Article |
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The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 −1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p<0.001) higher, while IFN-γ was significantly (p<0.001) lower in patients compared to that of the controls. There was a significant effect of gene polymorphisms of IL-10 (p<0.05) and IFN-γ (p<0.001) in occurrence of atopic asthma and increased IgE level. Polymorphism of IFN-γ gene had an effect on the serum level of IFN-γ. In conclusion, IFN-γ gene polymorphism at position +874 and IL-10 gene polymorphism at position −1082A/G are genetic determinants which contribute to susceptibility to atopic asthma in children from Saudi Arabia.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/j.cellimm.2014.03.006</identifier><identifier>PMID: 24709010</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Asthma - blood ; Asthma - genetics ; Atopic asthma ; Child ; Cytokines ; Female ; Gene polymorphism ; Genetic Predisposition to Disease ; Genotype ; Genotyping ; Humans ; IL-10 ; IL-13 ; IL-4 ; Immunoglobulin E - blood ; Interferon γ (IFN-γ) ; Interferon-gamma - blood ; Interferon-gamma - genetics ; Interleukin-10 - blood ; Interleukin-10 - genetics ; Interleukin-13 - blood ; Interleukin-4 - blood ; Male ; Polymorphism, Single Nucleotide ; Saudi Arabia</subject><ispartof>Cellular immunology, 2014-05, Vol.289 (1-2), p.21-26</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-fa975cb97982c2592012b29e4c7587ecdc0c4234c5bfc889a37f35c14f6e53503</citedby><cites>FETCH-LOGICAL-c280t-fa975cb97982c2592012b29e4c7587ecdc0c4234c5bfc889a37f35c14f6e53503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0008874914000409$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24709010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussein, Y.M.</creatorcontrib><creatorcontrib>Alzahrani, S.S.</creatorcontrib><creatorcontrib>Alharthi, A.A.</creatorcontrib><creatorcontrib>Ghonaim, M.M.</creatorcontrib><creatorcontrib>Alhazmi, A.S.</creatorcontrib><creatorcontrib>Eed, E.M.</creatorcontrib><creatorcontrib>Shalaby, S.M.</creatorcontrib><title>Association of serum cytokines levels, interleukin 10 −1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>•Levels of IL-4 and IL-13 were significantly higher in atopic asthmatics.•IFN-γ levels were significantly lower in patients than controls.•No significant difference in IL-10 levels between atopic asthma and controls.•Significant association of IL-10 and IFN-γ SNPs with atopic asthma.•IFN-γ +874T/A gene polymorphism was associated with decreased IFN-γ levels.
The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 −1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p<0.001) higher, while IFN-γ was significantly (p<0.001) lower in patients compared to that of the controls. There was a significant effect of gene polymorphisms of IL-10 (p<0.05) and IFN-γ (p<0.001) in occurrence of atopic asthma and increased IgE level. Polymorphism of IFN-γ gene had an effect on the serum level of IFN-γ. In conclusion, IFN-γ gene polymorphism at position +874 and IL-10 gene polymorphism at position −1082A/G are genetic determinants which contribute to susceptibility to atopic asthma in children from Saudi Arabia.</description><subject>Asthma - blood</subject><subject>Asthma - genetics</subject><subject>Atopic asthma</subject><subject>Child</subject><subject>Cytokines</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Humans</subject><subject>IL-10</subject><subject>IL-13</subject><subject>IL-4</subject><subject>Immunoglobulin E - blood</subject><subject>Interferon γ (IFN-γ)</subject><subject>Interferon-gamma - blood</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-13 - blood</subject><subject>Interleukin-4 - blood</subject><subject>Male</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Saudi Arabia</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFu1DAUhi0EokPhCCAvkSDps51M4hUaVaUgVWJBWVuO86LxEMfBdlrNDVh3wUW4B4fgJHg0A1tWlt77nn_p_wh5yaBkwNYXu9LgOFrnSg6sKkGUAOtHZMVAQsHZWjwmKwBoi7ap5Bl5FuMOgLFKwlNyxqsmYwxW5McmRm-sTtZP1A80YlgcNfvkv9oJIx3xDsf4ltopYRhxyVPKgP7-_sCg5dcXG6qn_rgdMPip-PWTvsmRt3kz-3HvfJi3NrpI723aUp38bA3VMW2dpmZrxz7gRIfgHf2sl97STdCd1c_Jk0GPEV-c3nPy5f3V7eWH4ubT9cfLzU1heAupGLRsatPJRrbc8FrmKnjHJVamqdsGTW_AVFxUpu4G07ZSi2YQtWHVsMZa1CDOyevjv3Pw3xaMSTkbD8XqCf0SFau5bIUELjJaH1ETfIwBBzUH63TYKwbqoETt1EmJOihRIFRWku9enSKWzmH_7-qvgwy8OwK5aLyzGFQ0FieDvQ1okuq9_U_EH6w_oVA</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Hussein, Y.M.</creator><creator>Alzahrani, S.S.</creator><creator>Alharthi, A.A.</creator><creator>Ghonaim, M.M.</creator><creator>Alhazmi, A.S.</creator><creator>Eed, E.M.</creator><creator>Shalaby, S.M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Association of serum cytokines levels, interleukin 10 −1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia</title><author>Hussein, Y.M. ; Alzahrani, S.S. ; Alharthi, A.A. ; Ghonaim, M.M. ; Alhazmi, A.S. ; Eed, E.M. ; Shalaby, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-fa975cb97982c2592012b29e4c7587ecdc0c4234c5bfc889a37f35c14f6e53503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Asthma - blood</topic><topic>Asthma - genetics</topic><topic>Atopic asthma</topic><topic>Child</topic><topic>Cytokines</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotyping</topic><topic>Humans</topic><topic>IL-10</topic><topic>IL-13</topic><topic>IL-4</topic><topic>Immunoglobulin E - blood</topic><topic>Interferon γ (IFN-γ)</topic><topic>Interferon-gamma - blood</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-13 - blood</topic><topic>Interleukin-4 - blood</topic><topic>Male</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Saudi Arabia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussein, Y.M.</creatorcontrib><creatorcontrib>Alzahrani, S.S.</creatorcontrib><creatorcontrib>Alharthi, A.A.</creatorcontrib><creatorcontrib>Ghonaim, M.M.</creatorcontrib><creatorcontrib>Alhazmi, A.S.</creatorcontrib><creatorcontrib>Eed, E.M.</creatorcontrib><creatorcontrib>Shalaby, S.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussein, Y.M.</au><au>Alzahrani, S.S.</au><au>Alharthi, A.A.</au><au>Ghonaim, M.M.</au><au>Alhazmi, A.S.</au><au>Eed, E.M.</au><au>Shalaby, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of serum cytokines levels, interleukin 10 −1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>2014-05</date><risdate>2014</risdate><volume>289</volume><issue>1-2</issue><spage>21</spage><epage>26</epage><pages>21-26</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>•Levels of IL-4 and IL-13 were significantly higher in atopic asthmatics.•IFN-γ levels were significantly lower in patients than controls.•No significant difference in IL-10 levels between atopic asthma and controls.•Significant association of IL-10 and IFN-γ SNPs with atopic asthma.•IFN-γ +874T/A gene polymorphism was associated with decreased IFN-γ levels.
The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 −1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p<0.001) higher, while IFN-γ was significantly (p<0.001) lower in patients compared to that of the controls. There was a significant effect of gene polymorphisms of IL-10 (p<0.05) and IFN-γ (p<0.001) in occurrence of atopic asthma and increased IgE level. Polymorphism of IFN-γ gene had an effect on the serum level of IFN-γ. In conclusion, IFN-γ gene polymorphism at position +874 and IL-10 gene polymorphism at position −1082A/G are genetic determinants which contribute to susceptibility to atopic asthma in children from Saudi Arabia.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>24709010</pmid><doi>10.1016/j.cellimm.2014.03.006</doi><tpages>6</tpages></addata></record> |
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| subjects | Asthma - blood Asthma - genetics Atopic asthma Child Cytokines Female Gene polymorphism Genetic Predisposition to Disease Genotype Genotyping Humans IL-10 IL-13 IL-4 Immunoglobulin E - blood Interferon γ (IFN-γ) Interferon-gamma - blood Interferon-gamma - genetics Interleukin-10 - blood Interleukin-10 - genetics Interleukin-13 - blood Interleukin-4 - blood Male Polymorphism, Single Nucleotide Saudi Arabia |
| title | Association of serum cytokines levels, interleukin 10 −1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia |
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