Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase

The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaff...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell and tissue biology 2021, Vol.15 (3), p.301-309
Hauptverfasser: Ivanov, A. N., Chibrikova, Yu. A., Saveleva, M. S., Rogozhina, A. S., Norkin, I. A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 309
container_issue 3
container_start_page 301
container_title Cell and tissue biology
container_volume 15
creator Ivanov, A. N.
Chibrikova, Yu. A.
Saveleva, M. S.
Rogozhina, A. S.
Norkin, I. A.
description The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaffolds mineralized with vaterite for targeted delivery of alkaline phosphatase in white rats. Using subcutaneous implantation tests, it has been found that polycaprolactone/vaterite scaffolds containing alkaline phosphatase do not cause an evident inflammatory response, are actively vascularized, and are populated by connective tissue elements. This shows that they are promising for stimulation of bone tissue regeneration.
doi_str_mv 10.1134/S1990519X21030044
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2542692967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2542692967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1614-b18c1df49d659dc6c419069b9fd46f1eded5c6a1388ed4d68396b30ef0fe1eb13</originalsourceid><addsrcrecordid>eNp1kE9LAzEQxYMoWKsfwNuC59XMbjZujvW_ULDQCt6WbDJpU9PNmmwL_fZureJBPM1j5v1mhkfIOdBLgJxdTUEIWoB4y4DmlDJ2QAa7VlpkND_80f38mJzEuKSUUwZ0QOob65VftbKztXW22ybeJBPvtkq2wTupOt9gMlXSGO90Mgl-Y7Vt5slMhjl2O3WHzm4wfJEj9y6d7YnJwsd2ITsZ8ZQcGekinn3XIXl9uJ_dPqXjl8fn29E4VcCBpTWUCrRhQvNCaMUVA0G5qIXRjBtAjbpQXEJelqiZ5mUueJ1TNNQgYA35kFzs9_aPf6wxdtXSr0PTn6yygmVcZIJf9y7Yu1TwMQY0VRvsSoZtBbTaRVn9ibJnsj0Te28zx_C7-X_oEwP4d5c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2542692967</pqid></control><display><type>article</type><title>Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase</title><source>Springer Nature - Complete Springer Journals</source><creator>Ivanov, A. N. ; Chibrikova, Yu. A. ; Saveleva, M. S. ; Rogozhina, A. S. ; Norkin, I. A.</creator><creatorcontrib>Ivanov, A. N. ; Chibrikova, Yu. A. ; Saveleva, M. S. ; Rogozhina, A. S. ; Norkin, I. A.</creatorcontrib><description>The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaffolds mineralized with vaterite for targeted delivery of alkaline phosphatase in white rats. Using subcutaneous implantation tests, it has been found that polycaprolactone/vaterite scaffolds containing alkaline phosphatase do not cause an evident inflammatory response, are actively vascularized, and are populated by connective tissue elements. This shows that they are promising for stimulation of bone tissue regeneration.</description><identifier>ISSN: 1990-519X</identifier><identifier>EISSN: 1990-5203</identifier><identifier>DOI: 10.1134/S1990519X21030044</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Alkalies ; Alkaline phosphatase ; Biocompatibility ; Biomedical and Life Sciences ; Bone growth ; Bones ; Cell Biology ; Connective tissues ; Inflammation ; Life Sciences ; Osteogenesis ; Phosphatase ; Polycaprolactone ; Regeneration</subject><ispartof>Cell and tissue biology, 2021, Vol.15 (3), p.301-309</ispartof><rights>Pleiades Publishing, Ltd. 2021. ISSN 1990-519X, Cell and Tissue Biology, 2021, Vol. 15, No. 3, pp. 301–309. © Pleiades Publishing, Ltd., 2021. Russian Text © The Author(s), 2020, published in Tsitologiya, 2020, Vol. 62, No. 12, pp. 903–912.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1614-b18c1df49d659dc6c419069b9fd46f1eded5c6a1388ed4d68396b30ef0fe1eb13</citedby><cites>FETCH-LOGICAL-c1614-b18c1df49d659dc6c419069b9fd46f1eded5c6a1388ed4d68396b30ef0fe1eb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1990519X21030044$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1990519X21030044$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Ivanov, A. N.</creatorcontrib><creatorcontrib>Chibrikova, Yu. A.</creatorcontrib><creatorcontrib>Saveleva, M. S.</creatorcontrib><creatorcontrib>Rogozhina, A. S.</creatorcontrib><creatorcontrib>Norkin, I. A.</creatorcontrib><title>Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase</title><title>Cell and tissue biology</title><addtitle>Cell Tiss. Biol</addtitle><description>The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaffolds mineralized with vaterite for targeted delivery of alkaline phosphatase in white rats. Using subcutaneous implantation tests, it has been found that polycaprolactone/vaterite scaffolds containing alkaline phosphatase do not cause an evident inflammatory response, are actively vascularized, and are populated by connective tissue elements. This shows that they are promising for stimulation of bone tissue regeneration.</description><subject>Alkalies</subject><subject>Alkaline phosphatase</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Bone growth</subject><subject>Bones</subject><subject>Cell Biology</subject><subject>Connective tissues</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Osteogenesis</subject><subject>Phosphatase</subject><subject>Polycaprolactone</subject><subject>Regeneration</subject><issn>1990-519X</issn><issn>1990-5203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMoWKsfwNuC59XMbjZujvW_ULDQCt6WbDJpU9PNmmwL_fZureJBPM1j5v1mhkfIOdBLgJxdTUEIWoB4y4DmlDJ2QAa7VlpkND_80f38mJzEuKSUUwZ0QOob65VftbKztXW22ybeJBPvtkq2wTupOt9gMlXSGO90Mgl-Y7Vt5slMhjl2O3WHzm4wfJEj9y6d7YnJwsd2ITsZ8ZQcGekinn3XIXl9uJ_dPqXjl8fn29E4VcCBpTWUCrRhQvNCaMUVA0G5qIXRjBtAjbpQXEJelqiZ5mUueJ1TNNQgYA35kFzs9_aPf6wxdtXSr0PTn6yygmVcZIJf9y7Yu1TwMQY0VRvsSoZtBbTaRVn9ibJnsj0Te28zx_C7-X_oEwP4d5c</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Ivanov, A. N.</creator><creator>Chibrikova, Yu. A.</creator><creator>Saveleva, M. S.</creator><creator>Rogozhina, A. S.</creator><creator>Norkin, I. A.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2021</creationdate><title>Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase</title><author>Ivanov, A. N. ; Chibrikova, Yu. A. ; Saveleva, M. S. ; Rogozhina, A. S. ; Norkin, I. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1614-b18c1df49d659dc6c419069b9fd46f1eded5c6a1388ed4d68396b30ef0fe1eb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alkalies</topic><topic>Alkaline phosphatase</topic><topic>Biocompatibility</topic><topic>Biomedical and Life Sciences</topic><topic>Bone growth</topic><topic>Bones</topic><topic>Cell Biology</topic><topic>Connective tissues</topic><topic>Inflammation</topic><topic>Life Sciences</topic><topic>Osteogenesis</topic><topic>Phosphatase</topic><topic>Polycaprolactone</topic><topic>Regeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ivanov, A. N.</creatorcontrib><creatorcontrib>Chibrikova, Yu. A.</creatorcontrib><creatorcontrib>Saveleva, M. S.</creatorcontrib><creatorcontrib>Rogozhina, A. S.</creatorcontrib><creatorcontrib>Norkin, I. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Cell and tissue biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivanov, A. N.</au><au>Chibrikova, Yu. A.</au><au>Saveleva, M. S.</au><au>Rogozhina, A. S.</au><au>Norkin, I. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase</atitle><jtitle>Cell and tissue biology</jtitle><stitle>Cell Tiss. Biol</stitle><date>2021</date><risdate>2021</risdate><volume>15</volume><issue>3</issue><spage>301</spage><epage>309</epage><pages>301-309</pages><issn>1990-519X</issn><eissn>1990-5203</eissn><abstract>The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaffolds mineralized with vaterite for targeted delivery of alkaline phosphatase in white rats. Using subcutaneous implantation tests, it has been found that polycaprolactone/vaterite scaffolds containing alkaline phosphatase do not cause an evident inflammatory response, are actively vascularized, and are populated by connective tissue elements. This shows that they are promising for stimulation of bone tissue regeneration.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1990519X21030044</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1990-519X
ispartof Cell and tissue biology, 2021, Vol.15 (3), p.301-309
issn 1990-519X
1990-5203
language eng
recordid cdi_proquest_journals_2542692967
source Springer Nature - Complete Springer Journals
subjects Alkalies
Alkaline phosphatase
Biocompatibility
Biomedical and Life Sciences
Bone growth
Bones
Cell Biology
Connective tissues
Inflammation
Life Sciences
Osteogenesis
Phosphatase
Polycaprolactone
Regeneration
title Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T18%3A53%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biocompatibility%20of%20Polycaprolactone%20Scaffold%20Providing%20Targeting%20Delivery%20of%20Alkaline%20Phosphatase&rft.jtitle=Cell%20and%20tissue%20biology&rft.au=Ivanov,%20A.%20N.&rft.date=2021&rft.volume=15&rft.issue=3&rft.spage=301&rft.epage=309&rft.pages=301-309&rft.issn=1990-519X&rft.eissn=1990-5203&rft_id=info:doi/10.1134/S1990519X21030044&rft_dat=%3Cproquest_cross%3E2542692967%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2542692967&rft_id=info:pmid/&rfr_iscdi=true