Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase
The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaff...
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Veröffentlicht in: | Cell and tissue biology 2021, Vol.15 (3), p.301-309 |
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creator | Ivanov, A. N. Chibrikova, Yu. A. Saveleva, M. S. Rogozhina, A. S. Norkin, I. A. |
description | The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaffolds mineralized with vaterite for targeted delivery of alkaline phosphatase in white rats. Using subcutaneous implantation tests, it has been found that polycaprolactone/vaterite scaffolds containing alkaline phosphatase do not cause an evident inflammatory response, are actively vascularized, and are populated by connective tissue elements. This shows that they are promising for stimulation of bone tissue regeneration. |
doi_str_mv | 10.1134/S1990519X21030044 |
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This shows that they are promising for stimulation of bone tissue regeneration.</description><identifier>ISSN: 1990-519X</identifier><identifier>EISSN: 1990-5203</identifier><identifier>DOI: 10.1134/S1990519X21030044</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Alkalies ; Alkaline phosphatase ; Biocompatibility ; Biomedical and Life Sciences ; Bone growth ; Bones ; Cell Biology ; Connective tissues ; Inflammation ; Life Sciences ; Osteogenesis ; Phosphatase ; Polycaprolactone ; Regeneration</subject><ispartof>Cell and tissue biology, 2021, Vol.15 (3), p.301-309</ispartof><rights>Pleiades Publishing, Ltd. 2021. ISSN 1990-519X, Cell and Tissue Biology, 2021, Vol. 15, No. 3, pp. 301–309. © Pleiades Publishing, Ltd., 2021. 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This shows that they are promising for stimulation of bone tissue regeneration.</description><subject>Alkalies</subject><subject>Alkaline phosphatase</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Bone growth</subject><subject>Bones</subject><subject>Cell Biology</subject><subject>Connective tissues</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Osteogenesis</subject><subject>Phosphatase</subject><subject>Polycaprolactone</subject><subject>Regeneration</subject><issn>1990-519X</issn><issn>1990-5203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMoWKsfwNuC59XMbjZujvW_ULDQCt6WbDJpU9PNmmwL_fZureJBPM1j5v1mhkfIOdBLgJxdTUEIWoB4y4DmlDJ2QAa7VlpkND_80f38mJzEuKSUUwZ0QOob65VftbKztXW22ybeJBPvtkq2wTupOt9gMlXSGO90Mgl-Y7Vt5slMhjl2O3WHzm4wfJEj9y6d7YnJwsd2ITsZ8ZQcGekinn3XIXl9uJ_dPqXjl8fn29E4VcCBpTWUCrRhQvNCaMUVA0G5qIXRjBtAjbpQXEJelqiZ5mUueJ1TNNQgYA35kFzs9_aPf6wxdtXSr0PTn6yygmVcZIJf9y7Yu1TwMQY0VRvsSoZtBbTaRVn9ibJnsj0Te28zx_C7-X_oEwP4d5c</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Ivanov, A. 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subjects | Alkalies Alkaline phosphatase Biocompatibility Biomedical and Life Sciences Bone growth Bones Cell Biology Connective tissues Inflammation Life Sciences Osteogenesis Phosphatase Polycaprolactone Regeneration |
title | Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase |
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