Biocompatibility of Polycaprolactone Scaffold Providing Targeting Delivery of Alkaline Phosphatase

The gene for alkaline phosphatase is expressed at the earliest stages of osteogenesis thus determining the prospects for targeted delivery of this enzyme to stimulate the reparative processes of bone tissue using scaffolds. This study aimed at assessing the biocompatibility of polycaprolactone scaffolds mineralized with vaterite for targeted delivery of alkaline phosphatase in white rats. Using subcutaneous implantation tests, it has been found that polycaprolactone/vaterite scaffolds containing alkaline phosphatase do not cause an evident inflammatory response, are actively vascularized, and are populated by connective tissue elements. This shows that they are promising for stimulation of bone tissue regeneration.