Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD) activation and GABA concentration

Several recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD) response in the same region. In this study, we set out to investigate whether this coupling gener...

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Veröffentlicht in:PloS one 2015-02, Vol.10 (2), p.e0117531-e0117531
Hauptverfasser: Harris, Ashley D, Puts, Nicolaas A J, Anderson, Brian A, Yantis, Steven, Pekar, James J, Barker, Peter B, Edden, Richard A E
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container_title PloS one
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creator Harris, Ashley D
Puts, Nicolaas A J
Anderson, Brian A
Yantis, Steven
Pekar, James J
Barker, Peter B
Edden, Richard A E
description Several recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD) response in the same region. In this study, we set out to investigate whether this coupling generalizes across cortex. In 18 healthy participants, we performed edited MRS measurements of GABA and BOLD-fMRI experiments using regionally related activation paradigms. Regions and tasks were the: occipital cortex with a visual grating stimulus; auditory cortex with a white noise stimulus; sensorimotor cortex with a finger-tapping task; frontal eye field with a saccade task; and dorsolateral prefrontal cortex with a working memory task. In contrast to the prior literature, no correlation between GABA concentration and BOLD activation was detected in any region. The origin of this discrepancy is not clear. Subtle differences in study design or insufficient power may cause differing results; these and other potential reasons for the discrepant results are discussed. This negative result, although it should be interpreted with caution, has a larger sample size than prior positive results, and suggests that the relationship between GABA and the BOLD response may be more complex than previously thought.
doi_str_mv 10.1371/journal.pone.0117531
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subjects Acids
Acoustic Stimulation
Activation
Adult
Auditory Cortex - metabolism
Blood
Brain - physiology
Brain Mapping
Correlation
Correlation analysis
Cortex (auditory)
Cortex (frontal)
Cortex (occipital)
Cortex (somatosensory)
Female
Functional magnetic resonance imaging
GABA
gamma-Aminobutyric Acid - analysis
Humans
Magnetic Resonance Imaging
Male
Medical imaging
Menstruation
Mental task performance
Metabolism
Motor task performance
Occipital lobe
Oxygen - blood
Oxygenation
Prefrontal cortex
Radiology
Receptive field
Saccadic eye movements
Science
Sensorimotor Cortex - metabolism
Sensory integration
Short term memory
Somatosensory cortex
Spectrum analysis
Studies
Visual cortex
Visual stimuli
White noise
γ-Aminobutyric acid
title Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD) activation and GABA concentration
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