Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD) activation and GABA concentration
Several recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD) response in the same region. In this study, we set out to investigate whether this coupling gener...
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description | Several recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD) response in the same region. In this study, we set out to investigate whether this coupling generalizes across cortex. In 18 healthy participants, we performed edited MRS measurements of GABA and BOLD-fMRI experiments using regionally related activation paradigms. Regions and tasks were the: occipital cortex with a visual grating stimulus; auditory cortex with a white noise stimulus; sensorimotor cortex with a finger-tapping task; frontal eye field with a saccade task; and dorsolateral prefrontal cortex with a working memory task. In contrast to the prior literature, no correlation between GABA concentration and BOLD activation was detected in any region. The origin of this discrepancy is not clear. Subtle differences in study design or insufficient power may cause differing results; these and other potential reasons for the discrepant results are discussed. This negative result, although it should be interpreted with caution, has a larger sample size than prior positive results, and suggests that the relationship between GABA and the BOLD response may be more complex than previously thought. |
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In this study, we set out to investigate whether this coupling generalizes across cortex. In 18 healthy participants, we performed edited MRS measurements of GABA and BOLD-fMRI experiments using regionally related activation paradigms. Regions and tasks were the: occipital cortex with a visual grating stimulus; auditory cortex with a white noise stimulus; sensorimotor cortex with a finger-tapping task; frontal eye field with a saccade task; and dorsolateral prefrontal cortex with a working memory task. In contrast to the prior literature, no correlation between GABA concentration and BOLD activation was detected in any region. The origin of this discrepancy is not clear. Subtle differences in study design or insufficient power may cause differing results; these and other potential reasons for the discrepant results are discussed. This negative result, although it should be interpreted with caution, has a larger sample size than prior positive results, and suggests that the relationship between GABA and the BOLD response may be more complex than previously thought.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117531</identifier><identifier>PMID: 25699994</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Acoustic Stimulation ; Activation ; Adult ; Auditory Cortex - metabolism ; Blood ; Brain - physiology ; Brain Mapping ; Correlation ; Correlation analysis ; Cortex (auditory) ; Cortex (frontal) ; Cortex (occipital) ; Cortex (somatosensory) ; Female ; Functional magnetic resonance imaging ; GABA ; gamma-Aminobutyric Acid - analysis ; Humans ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Menstruation ; Mental task performance ; Metabolism ; Motor task performance ; Occipital lobe ; Oxygen - blood ; Oxygenation ; Prefrontal cortex ; Radiology ; Receptive field ; Saccadic eye movements ; Science ; Sensorimotor Cortex - metabolism ; Sensory integration ; Short term memory ; Somatosensory cortex ; Spectrum analysis ; Studies ; Visual cortex ; Visual stimuli ; White noise ; γ-Aminobutyric acid</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0117531-e0117531</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Harris et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Harris et al 2015 Harris et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-24b6fc41a36aa4e912f6105e5c8b32a6d6010aa5ea4b61100dcc2c6e83d98dcd3</citedby><cites>FETCH-LOGICAL-c692t-24b6fc41a36aa4e912f6105e5c8b32a6d6010aa5ea4b61100dcc2c6e83d98dcd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336183/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336183/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25699994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Luo, Xi</contributor><creatorcontrib>Harris, Ashley D</creatorcontrib><creatorcontrib>Puts, Nicolaas A J</creatorcontrib><creatorcontrib>Anderson, Brian A</creatorcontrib><creatorcontrib>Yantis, Steven</creatorcontrib><creatorcontrib>Pekar, James J</creatorcontrib><creatorcontrib>Barker, Peter B</creatorcontrib><creatorcontrib>Edden, Richard A E</creatorcontrib><title>Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD) activation and GABA concentration</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Several recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD) response in the same region. 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This negative result, although it should be interpreted with caution, has a larger sample size than prior positive results, and suggests that the relationship between GABA and the BOLD response may be more complex than previously thought.</description><subject>Acids</subject><subject>Acoustic Stimulation</subject><subject>Activation</subject><subject>Adult</subject><subject>Auditory Cortex - metabolism</subject><subject>Blood</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Cortex (auditory)</subject><subject>Cortex (frontal)</subject><subject>Cortex (occipital)</subject><subject>Cortex (somatosensory)</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>GABA</subject><subject>gamma-Aminobutyric Acid - analysis</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Menstruation</subject><subject>Mental task performance</subject><subject>Metabolism</subject><subject>Motor task performance</subject><subject>Occipital lobe</subject><subject>Oxygen - blood</subject><subject>Oxygenation</subject><subject>Prefrontal cortex</subject><subject>Radiology</subject><subject>Receptive field</subject><subject>Saccadic eye movements</subject><subject>Science</subject><subject>Sensorimotor Cortex - metabolism</subject><subject>Sensory integration</subject><subject>Short term memory</subject><subject>Somatosensory cortex</subject><subject>Spectrum analysis</subject><subject>Studies</subject><subject>Visual cortex</subject><subject>Visual stimuli</subject><subject>White noise</subject><subject>γ-Aminobutyric acid</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkLbRYu_4qY3SN2AUalTpfFxazn2SerJtUuclO1v8Itxm25q0S5ILhKfPO_rnHN8suw1wUPCRuTDTegar9xwFTwMMSGjnJEn2TEZMzoQFLOne-9H2YsYbzDOWSHE8-yI5mKcLn6c_bnqXGsHDdQ2JDdk_Rpia2vVpjUKFWoXgBpw23Vc2BUqof0N4FHVed32oqvrKSpdCAaF27safC92sAaHDKzAG_AtOj2fzz6dIZVU655Q3qDLyfkE6eB1Qppt-GX2rFIuwqvd8yT78eXz94uvg9n8cnoxmQ20GNN2QHkpKs2JYkIpDmNCK0FwDrkuSkaVMAITrFQOKoGEYGy0plpAwcy4MNqwk-xt77tyIcpdOaMkIhd5IfiIJmLaEyaoG7lq7FI1dzIoK7eB0NRSNa3VDiTm2pS4VAXlmmuiFOUMRK7EiJS83Hp93O3WlUswfbruwPTwi7cLWYe15IwJUrBkcLozaMKvLjVJLm3U4JzyELrtfxec5liMEvruH_Tx7HZUrVIC1lch7as3pnLCKSs2GEnU8BEq3QaWNvUNKpviB4KzA0FiWrhta9XFKKffrv-fnf88ZN_vsQtQrl3E4LrtwTwEeQ_qJsTYQPVQZILlZnTuqyE3oyN3o5Nkb_Yb9CC6nxX2F5JnFhQ</recordid><startdate>20150220</startdate><enddate>20150220</enddate><creator>Harris, Ashley D</creator><creator>Puts, Nicolaas A J</creator><creator>Anderson, Brian A</creator><creator>Yantis, Steven</creator><creator>Pekar, James J</creator><creator>Barker, Peter B</creator><creator>Edden, Richard A E</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150220</creationdate><title>Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD) activation and GABA concentration</title><author>Harris, Ashley D ; Puts, Nicolaas A J ; Anderson, Brian A ; Yantis, Steven ; Pekar, James J ; Barker, Peter B ; Edden, Richard A E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-24b6fc41a36aa4e912f6105e5c8b32a6d6010aa5ea4b61100dcc2c6e83d98dcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Acoustic Stimulation</topic><topic>Activation</topic><topic>Adult</topic><topic>Auditory Cortex - metabolism</topic><topic>Blood</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Cortex (auditory)</topic><topic>Cortex (frontal)</topic><topic>Cortex (occipital)</topic><topic>Cortex (somatosensory)</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>GABA</topic><topic>gamma-Aminobutyric Acid - analysis</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Menstruation</topic><topic>Mental task performance</topic><topic>Metabolism</topic><topic>Motor task performance</topic><topic>Occipital lobe</topic><topic>Oxygen - blood</topic><topic>Oxygenation</topic><topic>Prefrontal cortex</topic><topic>Radiology</topic><topic>Receptive field</topic><topic>Saccadic eye movements</topic><topic>Science</topic><topic>Sensorimotor Cortex - metabolism</topic><topic>Sensory integration</topic><topic>Short term memory</topic><topic>Somatosensory cortex</topic><topic>Spectrum analysis</topic><topic>Studies</topic><topic>Visual cortex</topic><topic>Visual stimuli</topic><topic>White noise</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, Ashley D</creatorcontrib><creatorcontrib>Puts, Nicolaas A J</creatorcontrib><creatorcontrib>Anderson, Brian A</creatorcontrib><creatorcontrib>Yantis, Steven</creatorcontrib><creatorcontrib>Pekar, James J</creatorcontrib><creatorcontrib>Barker, Peter B</creatorcontrib><creatorcontrib>Edden, Richard A E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, Ashley D</au><au>Puts, Nicolaas A J</au><au>Anderson, Brian A</au><au>Yantis, Steven</au><au>Pekar, James J</au><au>Barker, Peter B</au><au>Edden, Richard A E</au><au>Luo, Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD) activation and GABA concentration</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-20</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0117531</spage><epage>e0117531</epage><pages>e0117531-e0117531</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Several recent studies have reported an inter-individual correlation between regional GABA concentration, as measured by MRS, and the amplitude of the functional blood oxygenation level dependent (BOLD) response in the same region. In this study, we set out to investigate whether this coupling generalizes across cortex. In 18 healthy participants, we performed edited MRS measurements of GABA and BOLD-fMRI experiments using regionally related activation paradigms. Regions and tasks were the: occipital cortex with a visual grating stimulus; auditory cortex with a white noise stimulus; sensorimotor cortex with a finger-tapping task; frontal eye field with a saccade task; and dorsolateral prefrontal cortex with a working memory task. In contrast to the prior literature, no correlation between GABA concentration and BOLD activation was detected in any region. The origin of this discrepancy is not clear. Subtle differences in study design or insufficient power may cause differing results; these and other potential reasons for the discrepant results are discussed. This negative result, although it should be interpreted with caution, has a larger sample size than prior positive results, and suggests that the relationship between GABA and the BOLD response may be more complex than previously thought.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25699994</pmid><doi>10.1371/journal.pone.0117531</doi><oa>free_for_read</oa></addata></record> |
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subjects | Acids Acoustic Stimulation Activation Adult Auditory Cortex - metabolism Blood Brain - physiology Brain Mapping Correlation Correlation analysis Cortex (auditory) Cortex (frontal) Cortex (occipital) Cortex (somatosensory) Female Functional magnetic resonance imaging GABA gamma-Aminobutyric Acid - analysis Humans Magnetic Resonance Imaging Male Medical imaging Menstruation Mental task performance Metabolism Motor task performance Occipital lobe Oxygen - blood Oxygenation Prefrontal cortex Radiology Receptive field Saccadic eye movements Science Sensorimotor Cortex - metabolism Sensory integration Short term memory Somatosensory cortex Spectrum analysis Studies Visual cortex Visual stimuli White noise γ-Aminobutyric acid |
title | Multi-regional investigation of the relationship between functional MRI blood oxygenation level dependent (BOLD) activation and GABA concentration |
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