High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma

The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-res...

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Veröffentlicht in:Journal of cerebral blood flow and metabolism 2005-02, Vol.25 (2), p.145-153
Hauptverfasser: Adam, Jean-François, Nemoz, Christian, Bravin, Alberto, Fiedler, Stefan, Bayat, Sam, Monfraix, Sylvie, Berruyer, Gilles, Charvet, Anne Marie, Bas, Jean-François Le, Elleaume, Hélène, Estève, François
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Sprache:eng
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Zusammenfassung:The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood–brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47 × 47 μm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.
ISSN:0271-678X
1559-7016
DOI:10.1038/sj.jcbfm.9600017