High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma
The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-res...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2005-02, Vol.25 (2), p.145-153 |
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| container_title | Journal of cerebral blood flow and metabolism |
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| creator | Adam, Jean-François Nemoz, Christian Bravin, Alberto Fiedler, Stefan Bayat, Sam Monfraix, Sylvie Berruyer, Gilles Charvet, Anne Marie Bas, Jean-François Le Elleaume, Hélène Estève, François |
| description | The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood–brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47 × 47 μm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals. |
| doi_str_mv | 10.1038/sj.jcbfm.9600017 |
| format | Article |
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However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood–brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47 × 47 μm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1038/sj.jcbfm.9600017</identifier><identifier>PMID: 15678122</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Bioengineering ; Biological and medical sciences ; Blood-Brain Barrier ; Blood-Brain Barrier - diagnostic imaging ; Brain ; Brain - blood supply ; Brain Neoplasms ; Brain Neoplasms - diagnostic imaging ; Cell Line, Tumor ; Cerebrovascular Circulation ; Cerebrovascular Circulation - physiology ; Computer Science ; Diagnostic Imaging ; Diagnostic Imaging - methods ; Engineering Sciences ; Glioma ; Glioma - diagnostic imaging ; Image Processing, Computer-Assisted ; Image Processing, Computer-Assisted - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Life Sciences ; Medical sciences ; Nervous system ; Neurology ; Nuclear medicine ; Permeability ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Signal and Image processing ; Synchrotrons ; Tomography, X-Ray Computed ; Tomography, X-Ray Computed - methods ; Ultrasonic investigative techniques ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of cerebral blood flow and metabolism, 2005-02, Vol.25 (2), p.145-153</ispartof><rights>2005 ISCBFM</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Feb 2005</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-5fdd1dad8001407afe9ddde74979a3e36ca47d7f3135d531c6867842fce0b4ec3</citedby><cites>FETCH-LOGICAL-c493t-5fdd1dad8001407afe9ddde74979a3e36ca47d7f3135d531c6867842fce0b4ec3</cites><orcidid>0000-0001-6868-2755 ; 0000-0002-3991-9503 ; 0000-0002-8565-0293</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600017$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1038/sj.jcbfm.9600017$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,780,784,885,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16661861$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15678122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00388911$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Adam, Jean-François</creatorcontrib><creatorcontrib>Nemoz, Christian</creatorcontrib><creatorcontrib>Bravin, Alberto</creatorcontrib><creatorcontrib>Fiedler, Stefan</creatorcontrib><creatorcontrib>Bayat, Sam</creatorcontrib><creatorcontrib>Monfraix, Sylvie</creatorcontrib><creatorcontrib>Berruyer, Gilles</creatorcontrib><creatorcontrib>Charvet, Anne Marie</creatorcontrib><creatorcontrib>Bas, Jean-François Le</creatorcontrib><creatorcontrib>Elleaume, Hélène</creatorcontrib><creatorcontrib>Estève, François</creatorcontrib><title>High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood–brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47 × 47 μm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.</description><subject>Animals</subject><subject>Bioengineering</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier</subject><subject>Blood-Brain Barrier - diagnostic imaging</subject><subject>Brain</subject><subject>Brain - blood supply</subject><subject>Brain Neoplasms</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Cell Line, Tumor</subject><subject>Cerebrovascular Circulation</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Computer Science</subject><subject>Diagnostic Imaging</subject><subject>Diagnostic Imaging - methods</subject><subject>Engineering Sciences</subject><subject>Glioma</subject><subject>Glioma - diagnostic imaging</subject><subject>Image Processing, Computer-Assisted</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Nuclear medicine</subject><subject>Permeability</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Signal and Image processing</subject><subject>Synchrotrons</subject><subject>Tomography, X-Ray Computed</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Ultrasonic investigative techniques</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUGL1DAUx4so7rh696IEQU92TJq2ab0ti-sIA14UvIXXJO2ktMlskg70G_kxzWzrDnjwkoS83_u_9_4vSV4TvCWYVp98v-1F047busQYE_Yk2ZCiqFOGSfk02eCMkbRk1a-r5IX3fUQqWhTPkytSxF-SZZvk9053h9Qpb4cpaGtQM1gr08aBjm9wTiuHjsqNCho96DAjMHKB0CnmjArpETptOjT583k_gQk6QNAnhfxsxMHZ4KKwA6nhoYSw43EKSqJgR9s5OB7mz8iHSc4oRsGgu7qKeEBLF92g7Qgvk2ctDF69Wu_r5Ofdlx-3u3T__eu325t9KvKahrRopSQSZBXtyDGDVtVSSsXymtVAFS0F5EyylhJayIISUVbRijxrhcJNrgS9Tj4uugcY-NHF4dzMLWi-u9lzbXy0guPofVUTciIR_7DgR2fvJ-UDH7UXahjAKDt5XjJaMYaLCL77B-zt5EwchWekzikh-VkNL5Bw1nun2scOCObnjXPf84eN83XjMeXtqjs1o5KXhHXFEXi_AuAFDK0DI7S_cGVZkqo8104XzkOnLs39p_CbhTcQJqceBf_G_wDshdHp</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Adam, Jean-François</creator><creator>Nemoz, Christian</creator><creator>Bravin, Alberto</creator><creator>Fiedler, Stefan</creator><creator>Bayat, Sam</creator><creator>Monfraix, Sylvie</creator><creator>Berruyer, Gilles</creator><creator>Charvet, Anne Marie</creator><creator>Bas, Jean-François Le</creator><creator>Elleaume, Hélène</creator><creator>Estève, François</creator><general>SAGE Publications</general><general>Lippincott Williams & Wilkins</general><general>Sage Publications Ltd</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-6868-2755</orcidid><orcidid>https://orcid.org/0000-0002-3991-9503</orcidid><orcidid>https://orcid.org/0000-0002-8565-0293</orcidid></search><sort><creationdate>20050201</creationdate><title>High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma</title><author>Adam, Jean-François ; Nemoz, Christian ; Bravin, Alberto ; Fiedler, Stefan ; Bayat, Sam ; Monfraix, Sylvie ; Berruyer, Gilles ; Charvet, Anne Marie ; Bas, Jean-François Le ; Elleaume, Hélène ; Estève, François</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-5fdd1dad8001407afe9ddde74979a3e36ca47d7f3135d531c6867842fce0b4ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Bioengineering</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier</topic><topic>Blood-Brain Barrier - diagnostic imaging</topic><topic>Brain</topic><topic>Brain - blood supply</topic><topic>Brain Neoplasms</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Cell Line, Tumor</topic><topic>Cerebrovascular Circulation</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Computer Science</topic><topic>Diagnostic Imaging</topic><topic>Diagnostic Imaging - methods</topic><topic>Engineering Sciences</topic><topic>Glioma</topic><topic>Glioma - diagnostic imaging</topic><topic>Image Processing, Computer-Assisted</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Nuclear medicine</topic><topic>Permeability</topic><topic>Radiodiagnosis. 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However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood–brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47 × 47 μm2 pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>15678122</pmid><doi>10.1038/sj.jcbfm.9600017</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6868-2755</orcidid><orcidid>https://orcid.org/0000-0002-3991-9503</orcidid><orcidid>https://orcid.org/0000-0002-8565-0293</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-678X |
| ispartof | Journal of cerebral blood flow and metabolism, 2005-02, Vol.25 (2), p.145-153 |
| issn | 0271-678X 1559-7016 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_00388911v1 |
| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Animals Bioengineering Biological and medical sciences Blood-Brain Barrier Blood-Brain Barrier - diagnostic imaging Brain Brain - blood supply Brain Neoplasms Brain Neoplasms - diagnostic imaging Cell Line, Tumor Cerebrovascular Circulation Cerebrovascular Circulation - physiology Computer Science Diagnostic Imaging Diagnostic Imaging - methods Engineering Sciences Glioma Glioma - diagnostic imaging Image Processing, Computer-Assisted Image Processing, Computer-Assisted - methods Investigative techniques, diagnostic techniques (general aspects) Life Sciences Medical sciences Nervous system Neurology Nuclear medicine Permeability Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Signal and Image processing Synchrotrons Tomography, X-Ray Computed Tomography, X-Ray Computed - methods Ultrasonic investigative techniques Vascular diseases and vascular malformations of the nervous system |
| title | High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma |
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