Bifunctional compound and pharmaceutical composition comprising the bifunctional compound, and use thereof for preparation of medicament for treating androgen receptor related diseases

Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I): ABM-L-CLM (I); wherein: ABM is an androgen receptor binding moiety; -L- is a linking moiety; and CLM is a cere...

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Bibliographische Detailangaben
Hauptverfasser: CHEN, HUNGUAN, CHOU, CHIHANG, LIN, CHUIANG, CHENG, PEIIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I): ABM-L-CLM (I); wherein: ABM is an androgen receptor binding moiety; -L- is a linking moiety; and CLM is a cereblon E3 ubiquitin ligase binding moiety represented by Formula (II)-1: wherein one end of the -L- is covalently joined to Q3, Q4, Q5 or Q6; and the other end of the -L- is covalently joined to the ABM. Also provided are a pharmaceutical composition comprising the bifunctional compound and a method for treating an androgen receptor related disease or disorder by administering the bifunctional compound.