Bifunctional compound and pharmaceutical composition comprising the bifunctional compound, and use thereof for preparation of medicament for treating androgen receptor related diseases

Bifunctional compound and pharmaceutical composition comprising the bifunctional compound, and use thereof for preparation of medicament for treating androgen receptor related diseases

Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I): ABM-L-CLM (I); wherein: ABM is an androgen receptor binding moiety; -L- is a linking moiety; and CLM is a cere...

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Hauptverfasser: CHEN, HUNGUAN, CHOU, CHIHANG, LIN, CHUIANG, CHENG, PEIIN
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator CHEN, HUNGUAN
CHOU, CHIHANG
LIN, CHUIANG
CHENG, PEIIN
description Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I): ABM-L-CLM (I); wherein: ABM is an androgen receptor binding moiety; -L- is a linking moiety; and CLM is a cereblon E3 ubiquitin ligase binding moiety represented by Formula (II)-1: wherein one end of the -L- is covalently joined to Q3, Q4, Q5 or Q6; and the other end of the -L- is covalently joined to the ABM. Also provided are a pharmaceutical composition comprising the bifunctional compound and a method for treating an androgen receptor related disease or disorder by administering the bifunctional compound.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Bifunctional compound and pharmaceutical composition comprising the bifunctional compound, and use thereof for preparation of medicament for treating androgen receptor related diseases
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