Fremgangsmåte til fremstilling av vancomycinantibiotikum

PCT No. PCT/HU90/00079 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed Nov. 27, 1990 PCT Pub. No. WO91/08300 PCT Pub. Date Jun. 13, 1991.The invention relates to a process for preparation of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a s...

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Hauptverfasser: NAGY, MARIANN, ANDRASI, ANDRAS, VARGA, ILONA, MURI, VIOLA, FINANCSEK, ISTVAN, KOCSIS, GEZA, KOLLAR, ENDRE, GARAMVOELGYI, MIHALY, SZOKE, LASZLONE, ZLATOS, GABRIELLA, UDVARDY, AGNES, JARAI, MIKOS, KEGL, LASZLO
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creator NAGY, MARIANN
ANDRASI, ANDRAS
VARGA, ILONA
MURI, VIOLA
FINANCSEK, ISTVAN
KOCSIS, GEZA
KOLLAR, ENDRE
GARAMVOELGYI, MIHALY
SZOKE, LASZLONE
ZLATOS, GABRIELLA
UDVARDY, AGNES
JARAI, MIKOS
KEGL, LASZLO
description PCT No. PCT/HU90/00079 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed Nov. 27, 1990 PCT Pub. No. WO91/08300 PCT Pub. Date Jun. 13, 1991.The invention relates to a process for preparation of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a strain belonging to the Micropolyspora species in a culture-medium containing assimilable carbon and nitrogen sources as well as mineral salts. According to the invention as microorganisms the aminoglycoside-resistant NCAIM 001092 and NCAIM 001093 mutants of the strain belonging to the Micropolyspora orientalis species are used. Nitrates are suitable mineral salts in the fermentation. Soy flour, glycerol, calcium gluconate, starch are useful carbon sources. The fermentation is carried out preferably at a temperature of 29 DEG -30 DEG C. The vancomycin antibiotic produced in the fermentation is separated by using reverse osmosis and ultrafiltration following ion-exchange chromatography.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
MARINE PROPULSION OR STEERING
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PROCESSES USING MICROORGANISMS
RELATED EQUIPMENT
SHIPS OR OTHER WATERBORNE VESSELS
SPIRITS
TRANSPORTING
VINEGAR
WINE
title Fremgangsmåte til fremstilling av vancomycinantibiotikum
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