Fremgangsmåte til fremstilling av vancomycinantibiotikum

PCT No. PCT/HU90/00079 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed Nov. 27, 1990 PCT Pub. No. WO91/08300 PCT Pub. Date Jun. 13, 1991.The invention relates to a process for preparation of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a s...

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Hauptverfasser:	NAGY, MARIANN, ANDRASI, ANDRAS, VARGA, ILONA, MURI, VIOLA, FINANCSEK, ISTVAN, KOCSIS, GEZA, KOLLAR, ENDRE, GARAMVOELGYI, MIHALY, SZOKE, LASZLONE, ZLATOS, GABRIELLA, UDVARDY, AGNES, JARAI, MIKOS, KEGL, LASZLO
Format:	Patent
Sprache:	nor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE MARINE PROPULSION OR STEERING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PROCESSES USING MICROORGANISMS RELATED EQUIPMENT SHIPS OR OTHER WATERBORNE VESSELS SPIRITS TRANSPORTING VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/HU90/00079 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed Nov. 27, 1990 PCT Pub. No. WO91/08300 PCT Pub. Date Jun. 13, 1991.The invention relates to a process for preparation of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a strain belonging to the Micropolyspora species in a culture-medium containing assimilable carbon and nitrogen sources as well as mineral salts. According to the invention as microorganisms the aminoglycoside-resistant NCAIM 001092 and NCAIM 001093 mutants of the strain belonging to the Micropolyspora orientalis species are used. Nitrates are suitable mineral salts in the fermentation. Soy flour, glycerol, calcium gluconate, starch are useful carbon sources. The fermentation is carried out preferably at a temperature of 29 DEG -30 DEG C. The vancomycin antibiotic produced in the fermentation is separated by using reverse osmosis and ultrafiltration following ion-exchange chromatography.