METHOD FOR PRODUCING PEPTIDE COMPOUND

METHOD FOR PRODUCING PEPTIDE COMPOUND

An object of the present invention is to provide a method for producing a peptide with high efficiency.A method for producing a peptide which comprises the following Steps (1) and (2).(1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino a...

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Hauptverfasser: YASUDA Naohiko, NAGAYA Akihiro, HANDA Michiharu, KOUSAKA Hiroyuki
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator YASUDA Naohiko
NAGAYA Akihiro
HANDA Michiharu
KOUSAKA Hiroyuki
description An object of the present invention is to provide a method for producing a peptide with high efficiency.A method for producing a peptide which comprises the following Steps (1) and (2).(1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino acid or an N-protected peptide represented by the formula (I):[wherein,Y represents an amino acid in which a C-terminal is unprotected or a peptide in which a C-terminal is unprotected,R1, R2 and R3 each independently represent an aliphatic hydrocarbon group which may have a substituent(s),a total number of the carbon atoms in the R1R2R3Si group is 10 or more, andthe R1R2R3SiOC(O) group is bonded to the N-terminal in Y.](2) a step of removing the protective group at the C-terminal of the peptide obtained in Step (1).
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title METHOD FOR PRODUCING PEPTIDE COMPOUND
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