METHOD FOR PRODUCING PEPTIDE COMPOUND
An object of the present invention is to provide a method for producing a peptide with high efficiency.A method for producing a peptide which comprises the following Steps (1) and (2).(1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino a...
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Format: | Patent |
Sprache: | eng ; fre ; ger |
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Zusammenfassung: | An object of the present invention is to provide a method for producing a peptide with high efficiency.A method for producing a peptide which comprises the following Steps (1) and (2).(1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino acid or an N-protected peptide represented by the formula (I):[wherein,Y represents an amino acid in which a C-terminal is unprotected or a peptide in which a C-terminal is unprotected,R1, R2 and R3 each independently represent an aliphatic hydrocarbon group which may have a substituent(s),a total number of the carbon atoms in the R1R2R3Si group is 10 or more, andthe R1R2R3SiOC(O) group is bonded to the N-terminal in Y.](2) a step of removing the protective group at the C-terminal of the peptide obtained in Step (1). |
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