Use of heterocyclic carbaldehyde derivatives against sickle cell anemia

The invention provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hy...

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Bibliographische Detailangaben
Hauptverfasser: DANSO-DANQUAH, RICHMOND, BURNETT, JAMES C, ABRAHAM, DONALD J, SAFO, MARTIN K, JOSHI, GAJANAN S, NOKURI, SAMUEL, MUSAYEV, FAIK N
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The invention provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.