Use of heterocyclic carbaldehyde derivatives against sickle cell anemia

The invention provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hy...

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Hauptverfasser:	DANSO-DANQUAH, RICHMOND, BURNETT, JAMES C, ABRAHAM, DONALD J, SAFO, MARTIN K, JOSHI, GAJANAN S, NOKURI, SAMUEL, MUSAYEV, FAIK N
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	DANSO-DANQUAH, RICHMOND BURNETT, JAMES C ABRAHAM, DONALD J SAFO, MARTIN K JOSHI, GAJANAN S NOKURI, SAMUEL MUSAYEV, FAIK N
description	The invention provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Use of heterocyclic carbaldehyde derivatives against sickle cell anemia
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