METHOD OF 2,2-DIMETHYL-5-(2,5-DI-METHYL-PHENOXY) PENTANOIC ACID PREPARATION, INTERMEDIATES AND METHOD OF INTERMEDIATES PREPARATION

The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optio...

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Hauptverfasser: SIMAY ANTAL DR.,HU, NAGY KALMAN DR.,HU, VERECZKEY GYORGYI DR.,HU, KOVACS GABOR DR.,HU, KOVACS EVA DR.,HU, FEHER GABOR DR.,HU, TOLDY LAJOS DR.,HU, ZUBOVICS ZOLTAN DR.,HU, KRASZNAI GYORGY,HU, SZEDERKENYI FERENC DR.,HU, MORAVCSIK IMRE,HU
Format: Patent
Sprache:eng
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Zusammenfassung:The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group-with an alkali salt of 2,5-dimethylphenol of Formula (II) (II) or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. (XI) Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.