METHOD OF 2,2-DIMETHYL-5-(2,5-DI-METHYL-PHENOXY) PENTANOIC ACID PREPARATION, INTERMEDIATES AND METHOD OF INTERMEDIATES PREPARATION
The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optio...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SIMAY ANTAL DR.,HU NAGY KALMAN DR.,HU VERECZKEY GYORGYI DR.,HU KOVACS GABOR DR.,HU KOVACS EVA DR.,HU FEHER GABOR DR.,HU TOLDY LAJOS DR.,HU ZUBOVICS ZOLTAN DR.,HU KRASZNAI GYORGY,HU SZEDERKENYI FERENC DR.,HU MORAVCSIK IMRE,HU |
| description | The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group-with an alkali salt of 2,5-dimethylphenol of Formula (II) (II) or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. (XI) Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CS9101359A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CS9101359A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CS9101359A23</originalsourceid><addsrcrecordid>eNrjZGjydQ3x8HdR8HdTMNIx0nXxBPEjfXRNdTWMdEyBfF2oQICHq59_RKSmQoCrX4ijn7-ns4Kjs6eLQkCQa4BjkGOIp7-fjoKnX4hrkK-ri6djiGuwgqOfiwLCeFQ5JG08DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeOdjS0MDQ2NTS0ciYCCUAxr87kg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD OF 2,2-DIMETHYL-5-(2,5-DI-METHYL-PHENOXY) PENTANOIC ACID PREPARATION, INTERMEDIATES AND METHOD OF INTERMEDIATES PREPARATION</title><source>esp@cenet</source><creator>SIMAY ANTAL DR.,HU ; NAGY KALMAN DR.,HU ; VERECZKEY GYORGYI DR.,HU ; KOVACS GABOR DR.,HU ; KOVACS EVA DR.,HU ; FEHER GABOR DR.,HU ; TOLDY LAJOS DR.,HU ; ZUBOVICS ZOLTAN DR.,HU ; KRASZNAI GYORGY,HU ; SZEDERKENYI FERENC DR.,HU ; MORAVCSIK IMRE,HU</creator><creatorcontrib>SIMAY ANTAL DR.,HU ; NAGY KALMAN DR.,HU ; VERECZKEY GYORGYI DR.,HU ; KOVACS GABOR DR.,HU ; KOVACS EVA DR.,HU ; FEHER GABOR DR.,HU ; TOLDY LAJOS DR.,HU ; ZUBOVICS ZOLTAN DR.,HU ; KRASZNAI GYORGY,HU ; SZEDERKENYI FERENC DR.,HU ; MORAVCSIK IMRE,HU</creatorcontrib><description>The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group-with an alkali salt of 2,5-dimethylphenol of Formula (II) (II) or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. (XI) Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.</description><edition>5</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911112&DB=EPODOC&CC=CS&NR=9101359A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911112&DB=EPODOC&CC=CS&NR=9101359A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIMAY ANTAL DR.,HU</creatorcontrib><creatorcontrib>NAGY KALMAN DR.,HU</creatorcontrib><creatorcontrib>VERECZKEY GYORGYI DR.,HU</creatorcontrib><creatorcontrib>KOVACS GABOR DR.,HU</creatorcontrib><creatorcontrib>KOVACS EVA DR.,HU</creatorcontrib><creatorcontrib>FEHER GABOR DR.,HU</creatorcontrib><creatorcontrib>TOLDY LAJOS DR.,HU</creatorcontrib><creatorcontrib>ZUBOVICS ZOLTAN DR.,HU</creatorcontrib><creatorcontrib>KRASZNAI GYORGY,HU</creatorcontrib><creatorcontrib>SZEDERKENYI FERENC DR.,HU</creatorcontrib><creatorcontrib>MORAVCSIK IMRE,HU</creatorcontrib><title>METHOD OF 2,2-DIMETHYL-5-(2,5-DI-METHYL-PHENOXY) PENTANOIC ACID PREPARATION, INTERMEDIATES AND METHOD OF INTERMEDIATES PREPARATION</title><description>The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group-with an alkali salt of 2,5-dimethylphenol of Formula (II) (II) or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. (XI) Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZGjydQ3x8HdR8HdTMNIx0nXxBPEjfXRNdTWMdEyBfF2oQICHq59_RKSmQoCrX4ijn7-ns4Kjs6eLQkCQa4BjkGOIp7-fjoKnX4hrkK-ri6djiGuwgqOfiwLCeFQ5JG08DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeOdjS0MDQ2NTS0ciYCCUAxr87kg</recordid><startdate>19911112</startdate><enddate>19911112</enddate><creator>SIMAY ANTAL DR.,HU</creator><creator>NAGY KALMAN DR.,HU</creator><creator>VERECZKEY GYORGYI DR.,HU</creator><creator>KOVACS GABOR DR.,HU</creator><creator>KOVACS EVA DR.,HU</creator><creator>FEHER GABOR DR.,HU</creator><creator>TOLDY LAJOS DR.,HU</creator><creator>ZUBOVICS ZOLTAN DR.,HU</creator><creator>KRASZNAI GYORGY,HU</creator><creator>SZEDERKENYI FERENC DR.,HU</creator><creator>MORAVCSIK IMRE,HU</creator><scope>EVB</scope></search><sort><creationdate>19911112</creationdate><title>METHOD OF 2,2-DIMETHYL-5-(2,5-DI-METHYL-PHENOXY) PENTANOIC ACID PREPARATION, INTERMEDIATES AND METHOD OF INTERMEDIATES PREPARATION</title><author>SIMAY ANTAL DR.,HU ; NAGY KALMAN DR.,HU ; VERECZKEY GYORGYI DR.,HU ; KOVACS GABOR DR.,HU ; KOVACS EVA DR.,HU ; FEHER GABOR DR.,HU ; TOLDY LAJOS DR.,HU ; ZUBOVICS ZOLTAN DR.,HU ; KRASZNAI GYORGY,HU ; SZEDERKENYI FERENC DR.,HU ; MORAVCSIK IMRE,HU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CS9101359A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1991</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>SIMAY ANTAL DR.,HU</creatorcontrib><creatorcontrib>NAGY KALMAN DR.,HU</creatorcontrib><creatorcontrib>VERECZKEY GYORGYI DR.,HU</creatorcontrib><creatorcontrib>KOVACS GABOR DR.,HU</creatorcontrib><creatorcontrib>KOVACS EVA DR.,HU</creatorcontrib><creatorcontrib>FEHER GABOR DR.,HU</creatorcontrib><creatorcontrib>TOLDY LAJOS DR.,HU</creatorcontrib><creatorcontrib>ZUBOVICS ZOLTAN DR.,HU</creatorcontrib><creatorcontrib>KRASZNAI GYORGY,HU</creatorcontrib><creatorcontrib>SZEDERKENYI FERENC DR.,HU</creatorcontrib><creatorcontrib>MORAVCSIK IMRE,HU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SIMAY ANTAL DR.,HU</au><au>NAGY KALMAN DR.,HU</au><au>VERECZKEY GYORGYI DR.,HU</au><au>KOVACS GABOR DR.,HU</au><au>KOVACS EVA DR.,HU</au><au>FEHER GABOR DR.,HU</au><au>TOLDY LAJOS DR.,HU</au><au>ZUBOVICS ZOLTAN DR.,HU</au><au>KRASZNAI GYORGY,HU</au><au>SZEDERKENYI FERENC DR.,HU</au><au>MORAVCSIK IMRE,HU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF 2,2-DIMETHYL-5-(2,5-DI-METHYL-PHENOXY) PENTANOIC ACID PREPARATION, INTERMEDIATES AND METHOD OF INTERMEDIATES PREPARATION</title><date>1991-11-12</date><risdate>1991</risdate><abstract>The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group-with an alkali salt of 2,5-dimethylphenol of Formula (II) (II) or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. (XI) Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_CS9101359A2 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING |
| title | METHOD OF 2,2-DIMETHYL-5-(2,5-DI-METHYL-PHENOXY) PENTANOIC ACID PREPARATION, INTERMEDIATES AND METHOD OF INTERMEDIATES PREPARATION |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T07%3A52%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SIMAY%20ANTAL%20DR.,HU&rft.date=1991-11-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECS9101359A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |