Preparation method and application of nanoparticles for mitochondrial targeted delivery of photosensitizer PCN-600

The invention provides a nano particle for mitochondrial targeted delivery of a photosensitizer PCN-600 and a preparation method of the nano particle. The porphyrin metal organic framework material PCN-600 with uniform morphology and uniform particle size can be synthesized, carboxylation modificati...

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Hauptverfasser: PENG NA, WANG YANLONG, WAN YUNFENG, YANG FUTING
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WANG YANLONG
WAN YUNFENG
YANG FUTING
description The invention provides a nano particle for mitochondrial targeted delivery of a photosensitizer PCN-600 and a preparation method of the nano particle. The porphyrin metal organic framework material PCN-600 with uniform morphology and uniform particle size can be synthesized, carboxylation modification and TPP-NH2 modification are carried out on the porphyrin metal organic framework material PCN-600, the stability of the photosensitizer is improved, early leakage or decomposition of the photosensitizer is avoided, and therefore the photodynamic therapy effect on tumors is effectively improved. 本发明提出的一种用于线粒体靶向递送光敏剂PCN-600的纳米粒子及制备方法。本发明能合成形貌均匀且粒径均一的卟啉类金属有机框架材料PCN-600,并对其进行羧基化修饰及TPP-NH2修饰,提高了光敏剂的稳定性,避免光敏剂的提前泄漏或分解,从而有效改善肿瘤的光动力治疗效果。
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Preparation method and application of nanoparticles for mitochondrial targeted delivery of photosensitizer PCN-600
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