Preparation method and application of nanoparticles for mitochondrial targeted delivery of photosensitizer PCN-600

The invention provides a nano particle for mitochondrial targeted delivery of a photosensitizer PCN-600 and a preparation method of the nano particle. The porphyrin metal organic framework material PCN-600 with uniform morphology and uniform particle size can be synthesized, carboxylation modification and TPP-NH2 modification are carried out on the porphyrin metal organic framework material PCN-600, the stability of the photosensitizer is improved, early leakage or decomposition of the photosensitizer is avoided, and therefore the photodynamic therapy effect on tumors is effectively improved. 本发明提出的一种用于线粒体靶向递送光敏剂PCN-600的纳米粒子及制备方法。本发明能合成形貌均匀且粒径均一的卟啉类金属有机框架材料PCN-600，并对其进行羧基化修饰及TPP-NH2修饰，提高了光敏剂的稳定性，避免光敏剂的提前泄漏或分解，从而有效改善肿瘤的光动力治疗效果。