PROCESS FOR THE PRODUCTION OF CARNITINE

PROCESS FOR THE PRODUCTION OF CARNITINE The process for the production of carnitine hydrochloride which involves reacting an ester of y-halo-acetoacetic acid having the formula: R2 is a lower alkyl group having 1 to 10 carbon atoms and X is halogen selected from the group consisting of chlorine or b...

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description PROCESS FOR THE PRODUCTION OF CARNITINE The process for the production of carnitine hydrochloride which involves reacting an ester of y-halo-acetoacetic acid having the formula: R2 is a lower alkyl group having 1 to 10 carbon atoms and X is halogen selected from the group consisting of chlorine or bromine, with an alkali alcoholate, which is present in a stoichiometrically excessive amount, at a temperature between 0.degree. and -40.degree.C. The reaction product is reacted with trimethylamine at a temperature between 10.degree. and 50.degree.C., a (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide is hydrogenated, a carnitine ester resulting. Then the carnitine ester is converted by means of aqueous hydrochloride acid into carnitine hydrochloride.
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The reaction product is reacted with trimethylamine at a temperature between 10.degree. and 50.degree.C., a (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide is hydrogenated, a carnitine ester resulting. 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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PROCESS FOR THE PRODUCTION OF CARNITINE
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