PROCESS FOR THE PRODUCTION OF CARNITINE

PROCESS FOR THE PRODUCTION OF CARNITINE

PROCESS FOR THE PRODUCTION OF CARNITINE The process for the production of carnitine hydrochloride which involves reacting an ester of y-halo-acetoacetic acid having the formula: R2 is a lower alkyl group having 1 to 10 carbon atoms and X is halogen selected from the group consisting of chlorine or b...

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1. Verfasser: TENUD, LEANDER
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:PROCESS FOR THE PRODUCTION OF CARNITINE The process for the production of carnitine hydrochloride which involves reacting an ester of y-halo-acetoacetic acid having the formula: R2 is a lower alkyl group having 1 to 10 carbon atoms and X is halogen selected from the group consisting of chlorine or bromine, with an alkali alcoholate, which is present in a stoichiometrically excessive amount, at a temperature between 0.degree. and -40.degree.C. The reaction product is reacted with trimethylamine at a temperature between 10.degree. and 50.degree.C., a (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide is hydrogenated, a carnitine ester resulting. Then the carnitine ester is converted by means of aqueous hydrochloride acid into carnitine hydrochloride.