Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis

Aim Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and...

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Veröffentlicht in:The journal of obstetrics and gynaecology research 2021-03, Vol.47 (3), p.941-948
Hauptverfasser: Sakurada, Takahiro, Matsushita, Hiroshi, Noguchi, Yasuyuki, Shinohara, Koichi, Watanabe, Kazushi, Wakatsuki, Akihiko
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Sprache:eng
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Zusammenfassung:Aim Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and free radical production in such women. Methods Women with endometriosis were treated with 20 μg EE + 3 mg drospirenone (DRSP) or 35 μg EE + 1 mg norethisterone (NET) for 3 months. Plasma concentrations of sex hormone‐binding globulin (SHBG), lipids, copper (Cu), derivatives of reactive oxygen metabolites (d‐ROMs), biological antioxidant potential (BAP), nitrite/nitrate, endothelin‐1 and asymmetrical dimethylarginine (ADMA) were measured before and after treatment. Flow‐mediated vasodilation (FMD) of the brachial artery was measured by ultrasonography. Results DRSP group, but not NET group, significantly increased FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while decreased endothelin‐1 concentrations. In both groups, ADMA and LDL cholesterol concentrations were significantly decreased, but triglyceride, SHBG, d‐ROMs, Cu and ceruloplasmin concentrations increased, and BAP concentrations did not change. DRSP group significantly increased HDL cholesterol concentrations, whereas NET group decreased its concentrations. Changes in triglyceride correlated positively either with changes in SHBG (r = 0.57, P 
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.14620