Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis
Aim Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2021-03, Vol.47 (3), p.941-948 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Sakurada, Takahiro Matsushita, Hiroshi Noguchi, Yasuyuki Shinohara, Koichi Watanabe, Kazushi Wakatsuki, Akihiko |
| description | Aim
Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and free radical production in such women.
Methods
Women with endometriosis were treated with 20 μg EE + 3 mg drospirenone (DRSP) or 35 μg EE + 1 mg norethisterone (NET) for 3 months. Plasma concentrations of sex hormone‐binding globulin (SHBG), lipids, copper (Cu), derivatives of reactive oxygen metabolites (d‐ROMs), biological antioxidant potential (BAP), nitrite/nitrate, endothelin‐1 and asymmetrical dimethylarginine (ADMA) were measured before and after treatment. Flow‐mediated vasodilation (FMD) of the brachial artery was measured by ultrasonography.
Results
DRSP group, but not NET group, significantly increased FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while decreased endothelin‐1 concentrations. In both groups, ADMA and LDL cholesterol concentrations were significantly decreased, but triglyceride, SHBG, d‐ROMs, Cu and ceruloplasmin concentrations increased, and BAP concentrations did not change. DRSP group significantly increased HDL cholesterol concentrations, whereas NET group decreased its concentrations. Changes in triglyceride correlated positively either with changes in SHBG (r = 0.57, P |
| doi_str_mv | 10.1111/jog.14620 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1111_jog_14620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2495138038</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3770-61ef082ed9c919c867f661d27795244b2ee50358c56d005bb854a5eefb2bb4f43</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhiMEoqVw4AWQJS4g2NZObCc5olUpoEq9wDlynPGuV44dbKerfTJej0l36QEJCV9seb75_9-eonjN6CXDdbULm0vGZUmfFOeM83pFayGf4rnibNXQWp4VL1LaUcrqljXPi7MKC7SU8rz4dW0M6JxIMET5IYYNeKvJFMMEMVt4KEzLdcrWEx3G3noYyN7mLYG8tf7gCNaiGmxwJHhyr5KenYoE_BDyFpxVjkRQOtt7mw8fyeRUGhVxdrJDWkyJiQBkUdCIotkwI4xSaLgPI_iTG-qNkKMNyaaXxTOjXIJXp_2i-PH5-vv6y-r27ubr-tPtSld1TVeSgaFNCUOrW9bqRtZGSjaUdd2KkvO-BBC0Eo0WcqBU9H0juBIApi_7nhteXRTvjroY6-eMD-1GmzQ4pzyEOXUlryUrRVu1iL79C92FOXpMh1QrWNXQqkHq_ZHSMaQUwXRTtKOKh47Rbpkmdm26h2ki--akOPcjDI_kn_Eh0ByBPfTBJG3Ba3jEKKWSCiYFxxNla5vV8q3rMPuMrR_-vxXpqxNtHRz-Hbn7dndzzP4bHxXN_w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2495138038</pqid></control><display><type>article</type><title>Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis</title><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Sakurada, Takahiro ; Matsushita, Hiroshi ; Noguchi, Yasuyuki ; Shinohara, Koichi ; Watanabe, Kazushi ; Wakatsuki, Akihiko</creator><creatorcontrib>Sakurada, Takahiro ; Matsushita, Hiroshi ; Noguchi, Yasuyuki ; Shinohara, Koichi ; Watanabe, Kazushi ; Wakatsuki, Akihiko</creatorcontrib><description>Aim
Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and free radical production in such women.
Methods
Women with endometriosis were treated with 20 μg EE + 3 mg drospirenone (DRSP) or 35 μg EE + 1 mg norethisterone (NET) for 3 months. Plasma concentrations of sex hormone‐binding globulin (SHBG), lipids, copper (Cu), derivatives of reactive oxygen metabolites (d‐ROMs), biological antioxidant potential (BAP), nitrite/nitrate, endothelin‐1 and asymmetrical dimethylarginine (ADMA) were measured before and after treatment. Flow‐mediated vasodilation (FMD) of the brachial artery was measured by ultrasonography.
Results
DRSP group, but not NET group, significantly increased FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while decreased endothelin‐1 concentrations. In both groups, ADMA and LDL cholesterol concentrations were significantly decreased, but triglyceride, SHBG, d‐ROMs, Cu and ceruloplasmin concentrations increased, and BAP concentrations did not change. DRSP group significantly increased HDL cholesterol concentrations, whereas NET group decreased its concentrations. Changes in triglyceride correlated positively either with changes in SHBG (r = 0.57, P < 0.001) or with small dense LDL cholesterol (r = 0.45, P = 0.005). Changes in Cu correlated positively with changes in d‐ROMs (r = 0.87, P < 0.001).
Conclusion
Androgenic properties of progestin may counteract EE's favorable effects on endothelial function and HDL cholesterol, while eliminating its adverse effects on increased triglyceride‐induced small dense LDL cholesterol in women with endometriosis.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14620</identifier><identifier>PMID: 33410266</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>17β-Estradiol ; Antioxidants ; Ceruloplasmin ; Cholesterol ; Endometriosis ; Endothelins ; Endothelium ; Ethinylestradiol ; free radical ; Free radicals ; Globulins ; HDL cholesterol ; High density lipoprotein ; Life Sciences & Biomedicine ; Lipid metabolism ; Lipids ; Low density lipoprotein ; Metabolites ; Obstetrics & Gynecology ; Oxidative stress ; Progestin ; Science & Technology ; Sex hormones ; small dense LDL cholesterol ; Testosterone ; vascular function ; Vasodilation</subject><ispartof>The journal of obstetrics and gynaecology research, 2021-03, Vol.47 (3), p.941-948</ispartof><rights>2021 Japan Society of Obstetrics and Gynecology</rights><rights>2021 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000605165400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3770-61ef082ed9c919c867f661d27795244b2ee50358c56d005bb854a5eefb2bb4f43</citedby><cites>FETCH-LOGICAL-c3770-61ef082ed9c919c867f661d27795244b2ee50358c56d005bb854a5eefb2bb4f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.14620$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.14620$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,39263,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33410266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakurada, Takahiro</creatorcontrib><creatorcontrib>Matsushita, Hiroshi</creatorcontrib><creatorcontrib>Noguchi, Yasuyuki</creatorcontrib><creatorcontrib>Shinohara, Koichi</creatorcontrib><creatorcontrib>Watanabe, Kazushi</creatorcontrib><creatorcontrib>Wakatsuki, Akihiko</creatorcontrib><title>Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J OBSTET GYNAECOL RE</addtitle><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and free radical production in such women.
Methods
Women with endometriosis were treated with 20 μg EE + 3 mg drospirenone (DRSP) or 35 μg EE + 1 mg norethisterone (NET) for 3 months. Plasma concentrations of sex hormone‐binding globulin (SHBG), lipids, copper (Cu), derivatives of reactive oxygen metabolites (d‐ROMs), biological antioxidant potential (BAP), nitrite/nitrate, endothelin‐1 and asymmetrical dimethylarginine (ADMA) were measured before and after treatment. Flow‐mediated vasodilation (FMD) of the brachial artery was measured by ultrasonography.
Results
DRSP group, but not NET group, significantly increased FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while decreased endothelin‐1 concentrations. In both groups, ADMA and LDL cholesterol concentrations were significantly decreased, but triglyceride, SHBG, d‐ROMs, Cu and ceruloplasmin concentrations increased, and BAP concentrations did not change. DRSP group significantly increased HDL cholesterol concentrations, whereas NET group decreased its concentrations. Changes in triglyceride correlated positively either with changes in SHBG (r = 0.57, P < 0.001) or with small dense LDL cholesterol (r = 0.45, P = 0.005). Changes in Cu correlated positively with changes in d‐ROMs (r = 0.87, P < 0.001).
Conclusion
Androgenic properties of progestin may counteract EE's favorable effects on endothelial function and HDL cholesterol, while eliminating its adverse effects on increased triglyceride‐induced small dense LDL cholesterol in women with endometriosis.</description><subject>17β-Estradiol</subject><subject>Antioxidants</subject><subject>Ceruloplasmin</subject><subject>Cholesterol</subject><subject>Endometriosis</subject><subject>Endothelins</subject><subject>Endothelium</subject><subject>Ethinylestradiol</subject><subject>free radical</subject><subject>Free radicals</subject><subject>Globulins</subject><subject>HDL cholesterol</subject><subject>High density lipoprotein</subject><subject>Life Sciences & Biomedicine</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Metabolites</subject><subject>Obstetrics & Gynecology</subject><subject>Oxidative stress</subject><subject>Progestin</subject><subject>Science & Technology</subject><subject>Sex hormones</subject><subject>small dense LDL cholesterol</subject><subject>Testosterone</subject><subject>vascular function</subject><subject>Vasodilation</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkcFu1DAQhiMEoqVw4AWQJS4g2NZObCc5olUpoEq9wDlynPGuV44dbKerfTJej0l36QEJCV9seb75_9-eonjN6CXDdbULm0vGZUmfFOeM83pFayGf4rnibNXQWp4VL1LaUcrqljXPi7MKC7SU8rz4dW0M6JxIMET5IYYNeKvJFMMEMVt4KEzLdcrWEx3G3noYyN7mLYG8tf7gCNaiGmxwJHhyr5KenYoE_BDyFpxVjkRQOtt7mw8fyeRUGhVxdrJDWkyJiQBkUdCIotkwI4xSaLgPI_iTG-qNkKMNyaaXxTOjXIJXp_2i-PH5-vv6y-r27ubr-tPtSld1TVeSgaFNCUOrW9bqRtZGSjaUdd2KkvO-BBC0Eo0WcqBU9H0juBIApi_7nhteXRTvjroY6-eMD-1GmzQ4pzyEOXUlryUrRVu1iL79C92FOXpMh1QrWNXQqkHq_ZHSMaQUwXRTtKOKh47Rbpkmdm26h2ki--akOPcjDI_kn_Eh0ByBPfTBJG3Ba3jEKKWSCiYFxxNla5vV8q3rMPuMrR_-vxXpqxNtHRz-Hbn7dndzzP4bHxXN_w</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Sakurada, Takahiro</creator><creator>Matsushita, Hiroshi</creator><creator>Noguchi, Yasuyuki</creator><creator>Shinohara, Koichi</creator><creator>Watanabe, Kazushi</creator><creator>Wakatsuki, Akihiko</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202103</creationdate><title>Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis</title><author>Sakurada, Takahiro ; Matsushita, Hiroshi ; Noguchi, Yasuyuki ; Shinohara, Koichi ; Watanabe, Kazushi ; Wakatsuki, Akihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3770-61ef082ed9c919c867f661d27795244b2ee50358c56d005bb854a5eefb2bb4f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>17β-Estradiol</topic><topic>Antioxidants</topic><topic>Ceruloplasmin</topic><topic>Cholesterol</topic><topic>Endometriosis</topic><topic>Endothelins</topic><topic>Endothelium</topic><topic>Ethinylestradiol</topic><topic>free radical</topic><topic>Free radicals</topic><topic>Globulins</topic><topic>HDL cholesterol</topic><topic>High density lipoprotein</topic><topic>Life Sciences & Biomedicine</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Metabolites</topic><topic>Obstetrics & Gynecology</topic><topic>Oxidative stress</topic><topic>Progestin</topic><topic>Science & Technology</topic><topic>Sex hormones</topic><topic>small dense LDL cholesterol</topic><topic>Testosterone</topic><topic>vascular function</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakurada, Takahiro</creatorcontrib><creatorcontrib>Matsushita, Hiroshi</creatorcontrib><creatorcontrib>Noguchi, Yasuyuki</creatorcontrib><creatorcontrib>Shinohara, Koichi</creatorcontrib><creatorcontrib>Watanabe, Kazushi</creatorcontrib><creatorcontrib>Wakatsuki, Akihiko</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakurada, Takahiro</au><au>Matsushita, Hiroshi</au><au>Noguchi, Yasuyuki</au><au>Shinohara, Koichi</au><au>Watanabe, Kazushi</au><au>Wakatsuki, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><stitle>J OBSTET GYNAECOL RE</stitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2021-03</date><risdate>2021</risdate><volume>47</volume><issue>3</issue><spage>941</spage><epage>948</epage><pages>941-948</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and free radical production in such women.
Methods
Women with endometriosis were treated with 20 μg EE + 3 mg drospirenone (DRSP) or 35 μg EE + 1 mg norethisterone (NET) for 3 months. Plasma concentrations of sex hormone‐binding globulin (SHBG), lipids, copper (Cu), derivatives of reactive oxygen metabolites (d‐ROMs), biological antioxidant potential (BAP), nitrite/nitrate, endothelin‐1 and asymmetrical dimethylarginine (ADMA) were measured before and after treatment. Flow‐mediated vasodilation (FMD) of the brachial artery was measured by ultrasonography.
Results
DRSP group, but not NET group, significantly increased FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while decreased endothelin‐1 concentrations. In both groups, ADMA and LDL cholesterol concentrations were significantly decreased, but triglyceride, SHBG, d‐ROMs, Cu and ceruloplasmin concentrations increased, and BAP concentrations did not change. DRSP group significantly increased HDL cholesterol concentrations, whereas NET group decreased its concentrations. Changes in triglyceride correlated positively either with changes in SHBG (r = 0.57, P < 0.001) or with small dense LDL cholesterol (r = 0.45, P = 0.005). Changes in Cu correlated positively with changes in d‐ROMs (r = 0.87, P < 0.001).
Conclusion
Androgenic properties of progestin may counteract EE's favorable effects on endothelial function and HDL cholesterol, while eliminating its adverse effects on increased triglyceride‐induced small dense LDL cholesterol in women with endometriosis.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>33410266</pmid><doi>10.1111/jog.14620</doi><tpages>8</tpages></addata></record> |
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| subjects | 17β-Estradiol Antioxidants Ceruloplasmin Cholesterol Endometriosis Endothelins Endothelium Ethinylestradiol free radical Free radicals Globulins HDL cholesterol High density lipoprotein Life Sciences & Biomedicine Lipid metabolism Lipids Low density lipoprotein Metabolites Obstetrics & Gynecology Oxidative stress Progestin Science & Technology Sex hormones small dense LDL cholesterol Testosterone vascular function Vasodilation |
| title | Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis |
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