Non-Invasive Cerebral Perfusion and Oxygenation Monitoring Augment Prolonged Field Care in a Non-Human Primate Model of Decompensated Hemorrhage and Resuscitation

BACKGROUND:Decompensated hemorrhagic shock (DHS) is the leading cause of preventable death in combat casualties. “Golden hour” resuscitation effects on cerebral blood flow and perfusion following DHS in prolonged field care (PFC) are not well investigated. Using an established non-human primate model of DHS, we hypothesized non-invasive regional tissue oxygenation (rSO2) and Transcranial Doppler (TCD) would correlate to the invasive measurement of partial pressure of oxygen (PtO2) and Mean Arterial Pressure (MAP) in guiding hypotensive resuscitation in a PFC setting. METHODS:Ten rhesus macaques underwent DHS followed by a 2hr PFC phase (T0-T120), and subsequent 4hr hospital resuscitation phase (T120-T360). Invasive monitoring (PtO2, MAP) were compared against non-invasive monitoring systems (rSO2, TCD). Results were analyzed using t-tests and one-way repeated measures ANOVA. Linear correlation was determined via Pearsonʼs r. Significance = p