Plasma Plasminogen Activator Inhibitor-1 in Angina Pectoris: Influence of Plasma Insulin and Acute-phase Response
Plasminogen activator Inhibitor-1 (PAI-1) is an Important physiological Inhibitor of fibrlnolysls. It circulates in blood both In free active form and In Inactive form comptexed with tissue type plasminogen activator (t-PA). Control mechanisms for Its synthesis and release from hepatocytes and endot...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1989-05, Vol.9 (3), p.362-367 |
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| container_title | Arteriosclerosis, thrombosis, and vascular biology |
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| creator | Juhan-Vague, Irene Alessi, Marie Christine Joly, Patrick Thirion, Xavier Vague, Philippe Declerck, Paul J Serradimigni, Andre Collen, Desire |
| description | Plasminogen activator Inhibitor-1 (PAI-1) is an Important physiological Inhibitor of fibrlnolysls. It circulates in blood both In free active form and In Inactive form comptexed with tissue type plasminogen activator (t-PA). Control mechanisms for Its synthesis and release from hepatocytes and endothellal cells are important In the pathogenesis of thrombosis. Possible risk factors for myocardlal Infarction Include high insulin and PAH levels, which correlate with one another In healthy subjects, and fibrlnogen, which together with PAI-1, Is an acute-phase reactant We therefore studied the Interrelationships between PAI-1, plasma Insulin, and acute-phase proteins In 67 patients with angina pectoris. Plasma Insulin correlated strongly (r=0.59, p |
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It circulates in blood both In free active form and In Inactive form comptexed with tissue type plasminogen activator (t-PA). Control mechanisms for Its synthesis and release from hepatocytes and endothellal cells are important In the pathogenesis of thrombosis. Possible risk factors for myocardlal Infarction Include high insulin and PAH levels, which correlate with one another In healthy subjects, and fibrlnogen, which together with PAI-1, Is an acute-phase reactant We therefore studied the Interrelationships between PAI-1, plasma Insulin, and acute-phase proteins In 67 patients with angina pectoris. Plasma Insulin correlated strongly (r=0.59, p<0.001) with PAI activity, free PAI-1 antigen (r=0.60, p<0.001), and total PAI-1 antigen (r=0.58, p<0.001). The acute-phase proteins, fibrlnogen and C-reactive protein, correlated significantly with t-PA antigen, total PAI-1 antigen, and PAH/t-PA complexes but not with PAI activity or free PAI-1. The results suggest that Insulin stimulates synthesis and release of free PAI-1 (probably via hepatocytes as previously shown with cell culture) and that endothellal cell synthesis and release of t-PA, together with PAI-1, reflects a nonspecific acute-phase response to chronic vascular disease. Hyperlnsullnemia found In patients with angina pectoris could play a role In the development of myocardlal Infarction via the Induction of high plasma PAI-1 activity.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><language>eng</language><publisher>American Heart Association, Inc</publisher><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 1989-05, Vol.9 (3), p.362-367</ispartof><rights>1989 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Juhan-Vague, Irene</creatorcontrib><creatorcontrib>Alessi, Marie Christine</creatorcontrib><creatorcontrib>Joly, Patrick</creatorcontrib><creatorcontrib>Thirion, Xavier</creatorcontrib><creatorcontrib>Vague, Philippe</creatorcontrib><creatorcontrib>Declerck, Paul J</creatorcontrib><creatorcontrib>Serradimigni, Andre</creatorcontrib><creatorcontrib>Collen, Desire</creatorcontrib><title>Plasma Plasminogen Activator Inhibitor-1 in Angina Pectoris: Influence of Plasma Insulin and Acute-phase Response</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><description>Plasminogen activator Inhibitor-1 (PAI-1) is an Important physiological Inhibitor of fibrlnolysls. It circulates in blood both In free active form and In Inactive form comptexed with tissue type plasminogen activator (t-PA). Control mechanisms for Its synthesis and release from hepatocytes and endothellal cells are important In the pathogenesis of thrombosis. Possible risk factors for myocardlal Infarction Include high insulin and PAH levels, which correlate with one another In healthy subjects, and fibrlnogen, which together with PAI-1, Is an acute-phase reactant We therefore studied the Interrelationships between PAI-1, plasma Insulin, and acute-phase proteins In 67 patients with angina pectoris. Plasma Insulin correlated strongly (r=0.59, p<0.001) with PAI activity, free PAI-1 antigen (r=0.60, p<0.001), and total PAI-1 antigen (r=0.58, p<0.001). The acute-phase proteins, fibrlnogen and C-reactive protein, correlated significantly with t-PA antigen, total PAI-1 antigen, and PAH/t-PA complexes but not with PAI activity or free PAI-1. The results suggest that Insulin stimulates synthesis and release of free PAI-1 (probably via hepatocytes as previously shown with cell culture) and that endothellal cell synthesis and release of t-PA, together with PAI-1, reflects a nonspecific acute-phase response to chronic vascular disease. Hyperlnsullnemia found In patients with angina pectoris could play a role In the development of myocardlal Infarction via the Induction of high plasma PAI-1 activity.</description><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqdTktuwjAQtaoiQaF38AUs2YkTGnYVagU7hNgjEybEYMaQccr1OyBOwGL03sz7aN7EyBSZVbbMy3fmelqporTZUHwQHbXWNsv0SFxXwdHZyQd4jAdA-V0n_-dS7OQSW7_zzJSRngU8eGQv1HzyNGO9CT1gDTI28tm0ROoDmx3uualPoC6tI5BroEtEgokYNC4QfD5xLOzvz2a-ULcYEnR0Cv0Num0LLqR2e380L3WhTPVV6YJXxWNM_mLsH2x3U4E</recordid><startdate>198905</startdate><enddate>198905</enddate><creator>Juhan-Vague, Irene</creator><creator>Alessi, Marie Christine</creator><creator>Joly, Patrick</creator><creator>Thirion, Xavier</creator><creator>Vague, Philippe</creator><creator>Declerck, Paul J</creator><creator>Serradimigni, Andre</creator><creator>Collen, Desire</creator><general>American Heart Association, Inc</general><scope/></search><sort><creationdate>198905</creationdate><title>Plasma Plasminogen Activator Inhibitor-1 in Angina Pectoris: Influence of Plasma Insulin and Acute-phase Response</title><author>Juhan-Vague, Irene ; Alessi, Marie Christine ; Joly, Patrick ; Thirion, Xavier ; Vague, Philippe ; Declerck, Paul J ; Serradimigni, Andre ; Collen, Desire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wolterskluwer_health_00043605-198905000-000113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juhan-Vague, Irene</creatorcontrib><creatorcontrib>Alessi, Marie Christine</creatorcontrib><creatorcontrib>Joly, Patrick</creatorcontrib><creatorcontrib>Thirion, Xavier</creatorcontrib><creatorcontrib>Vague, Philippe</creatorcontrib><creatorcontrib>Declerck, Paul J</creatorcontrib><creatorcontrib>Serradimigni, Andre</creatorcontrib><creatorcontrib>Collen, Desire</creatorcontrib><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juhan-Vague, Irene</au><au>Alessi, Marie Christine</au><au>Joly, Patrick</au><au>Thirion, Xavier</au><au>Vague, Philippe</au><au>Declerck, Paul J</au><au>Serradimigni, Andre</au><au>Collen, Desire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Plasminogen Activator Inhibitor-1 in Angina Pectoris: Influence of Plasma Insulin and Acute-phase Response</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><date>1989-05</date><risdate>1989</risdate><volume>9</volume><issue>3</issue><spage>362</spage><epage>367</epage><pages>362-367</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><abstract>Plasminogen activator Inhibitor-1 (PAI-1) is an Important physiological Inhibitor of fibrlnolysls. It circulates in blood both In free active form and In Inactive form comptexed with tissue type plasminogen activator (t-PA). Control mechanisms for Its synthesis and release from hepatocytes and endothellal cells are important In the pathogenesis of thrombosis. Possible risk factors for myocardlal Infarction Include high insulin and PAH levels, which correlate with one another In healthy subjects, and fibrlnogen, which together with PAI-1, Is an acute-phase reactant We therefore studied the Interrelationships between PAI-1, plasma Insulin, and acute-phase proteins In 67 patients with angina pectoris. Plasma Insulin correlated strongly (r=0.59, p<0.001) with PAI activity, free PAI-1 antigen (r=0.60, p<0.001), and total PAI-1 antigen (r=0.58, p<0.001). The acute-phase proteins, fibrlnogen and C-reactive protein, correlated significantly with t-PA antigen, total PAI-1 antigen, and PAH/t-PA complexes but not with PAI activity or free PAI-1. The results suggest that Insulin stimulates synthesis and release of free PAI-1 (probably via hepatocytes as previously shown with cell culture) and that endothellal cell synthesis and release of t-PA, together with PAI-1, reflects a nonspecific acute-phase response to chronic vascular disease. Hyperlnsullnemia found In patients with angina pectoris could play a role In the development of myocardlal Infarction via the Induction of high plasma PAI-1 activity.</abstract><pub>American Heart Association, Inc</pub></addata></record> |
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| source | Alma/SFX Local Collection |
| title | Plasma Plasminogen Activator Inhibitor-1 in Angina Pectoris: Influence of Plasma Insulin and Acute-phase Response |
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