Plasma Plasminogen Activator Inhibitor-1 in Angina Pectoris: Influence of Plasma Insulin and Acute-phase Response

Plasminogen activator Inhibitor-1 (PAI-1) is an Important physiological Inhibitor of fibrlnolysls. It circulates in blood both In free active form and In Inactive form comptexed with tissue type plasminogen activator (t-PA). Control mechanisms for Its synthesis and release from hepatocytes and endothellal cells are important In the pathogenesis of thrombosis. Possible risk factors for myocardlal Infarction Include high insulin and PAH levels, which correlate with one another In healthy subjects, and fibrlnogen, which together with PAI-1, Is an acute-phase reactant We therefore studied the Interrelationships between PAI-1, plasma Insulin, and acute-phase proteins In 67 patients with angina pectoris. Plasma Insulin correlated strongly (r=0.59, p