Abstract 13629: The Perspective of Using the Genetic Risk Score in Prediction of Cardiovascular Risk in Patients With Arterial Hypertension

IntroductionCardiovascular risk (CVR) prediction in patients with arterial hypertension (AH) is an important component of their long-lasting curative and preventive management. Nowdays the accumulated data of polymorphisms of candidate genes in AH form a reasonable prospect of using of genetic risk scores (GRS).HypothesisThe purpose was to form a model of GRS based on the evaluation of polymorphisms of candidate genes and total gene modification index (GMI), to compare this model with traditional stratification of CVR and to evaluate the perspective of its use for prognose in patients with AH.Methods254 patients with AH were examined (age 49,6 [28-72], male/female 122/132) and stratificated depend on CVR (ESC 2018). The patients were divided into 4 groupswith low, moderate, high or very high CVR. Then the analysis of polymorphisms of the following candidate genes were performed by PCRADD1:1378, AGT:704, AGT521, AGTR1:1166, AGTR21675, CYP11B2:-344, GNB3:825, NOS3:-786, NOS3:894. GMI was formed where the mark of 'pathological' homozygous polymorphism was 1.5 points, the heterozygous polymorphism - 1 point, 'normal' genotype - 0 point. GMI is calculated by the formulaGMI = (N / 13,5) х 100, where N is the sum of points of present genetic polymorphisms; 13,5 - the maximum possible number of points. It was offered the GRS, in which GMI from 0 to 20% was considered as low genetic risk, from 21 to 40 % - moderate risk, from 41 to 70% - high risk, from 71 to 100% - very high risk.ResultsAs a result of traditional stratification in group with low CVR were 28 patients, while in 70% of patients was similar low genetic risk (r=0,66, p