Abstract 13251: Coronary Flow Reserve by Cardiac Magnetic Resonance Imaging in Patients With Ischemic Cardiomyopathy With Diabetes Mellitus

IntroductionPhase-contrast cine magnetic resonance imaging (MRI) of the coronary sinus emerged as a non-invasive mean to quantify global coronary flow reserve (CFR). The purpose of this study is to investigate the prognostic value of MRI-CFR for ischemic cardiomyopathy (ICM) patients with and without diabetes mellitus.HypothesisMRI-CFR is a non-invasive prognostic marker for ICM patients with diabetes mellitus.MethodsSeventy-three ICM patients (mean age69±9 years; 69 (95%) male) were studied. Using a 1.5T MR scanner and 32 channel cardiac coils, coronary sinus blood flow (CBF) was quantified by phase contrast cine MRI at rest and during continuous injection of adenosine triphosphate (ATP). The CFR was defined as CBF during an ATP infusion (mL/min) / CBF at rest (mL/min). Adverse events were defined as occurrence of cardiac death or hospitalization due to heart failure exacerbation.ResultsTwenty-eight (38%) ICM patients had diabetes mellitus, and mean HbA1c was 6.9±1.0%. CFR was significantly lower in diabetic ICM patients in comparison to non-diabetic ICM patients (2.17±0.52 vs 2.44±0.51, p=0.030). During a median follow-up period of 2.6 years, 2 cardiac death and 8 hospitalization due to heart failure exacerbation were identified. Impairment of CFR (