Abstract 15569: Sex Difference on Deep Vein Thrombosis in Evacuees of the Kumamoto Earthquakes: Analyses for Acute and Chronic Phase Post Disaster

IntroductionAlthough higher prevalence rate of deep vein thrombosis (DVT) in female earthquake evacuees have been reported, sex difference in predictors of those, and the clinical course in the chronic phase have not been revealed.HypothesisIn DVT, which originally tend to occur in female, sex difference may also exist in its characteristics and in the remaining rate in the serial examination.MethodsKumamoto prefecture in Japan was struck by a series of earthquakes, including a magnitude (Mw) 6.5 on April 14 and Mw 7.3 on April 16, 2016. Three days after the Earthquakes, we performed DVT mobile screening for 3203 evacuees in shelters during 8-month time periods utilizing ultrasonography (US). The acute phase was set from the onset of disaster to 2 months, and the chronic phase was set from 2 to 8 months. Follow-up US surveys for the DVT positives were underwent at 2 to 14 months after the first screening in each positive.ResultsDVT was detected in 299 (9.3%) examinees. DVT prevalence was significantly higher in female (10.4% in female vs. 7.4% in male,p=0.046). In the acute phase, although a multivariate analysis revealed high age, taking sleep medications, comorbidity of dyslipidemia, leg edema, and lower extremity varix as DVT predictors in female, nothing was identified in male. In the chronic phase, DVT positive rate was comparable between the two groups (8.9% vs. 8.9%). Only high age in female, and skin redness in male was identified as significant predictor in the chronic phase. Serial examination for the 135 DVT positives (both in acute and chronic phase), 75 cases (55.6%) became DVT-negative during 2 to 14 months interval.Significantly higher remaining rate was observed in female DVT positives (50.0% in female vs. 20.0% in male,p=0.001).ConclusionsOnly in the acute phase of the Kumamoto Earthquake, DVT prevalence was significantly higher in female evacuees, and predictors of DVT depended on sex. Furthermore, DVT in female evacuees was more likely to remain than male.