Abstract 15297: High-Density Lipoprotein Function Associates With GlycA, a Novel Inflammation Marker, but Does Not Explain the Association Between GlycA and Incident Cardiovascular Events

BackgroundHigh-density lipoproteins (HDL) exert anti-atherosclerotic effects via reverse cholesterol transport, yet this process is impaired in the setting of inflammation. GlycA, a novel integrated glycosylation marker of five acute phase reactants, is linked to CV events. We assessed the hypothesis that GlycA is associated with impaired HDL function measures and that the association between GlycA and incident CV events is partially explained by dysfunctional HDL.MethodsBaseline measurements of HDL cholesterol (HDL-C), HDL particle concentration (HDL-P), and cholesterol efflux capacity were obtained from the Dallas Heart Study, a multi-ethnic cohort of 2225 adults without CVD. GlycA was derived from NMR spectral features. The primary end point was first nonfatal MI, nonfatal stroke, coronary revascularization, or CV death over a median of 11.4 years (N=171).ResultsMedian age was 43 with 56% women and 47% blacks. The correlation between GlycA and hs-CRP was 0.54 (p