Abstract 15074: One and Six Month OCT Follow up Among Drug Eluting Stents With Persistent, Bioresorbable or Without Polymer. The HORSEPOWER Multicenter and Prospective Study

One and six month OCT follow up among drug Eluting stents with Persistent, bioresorbable or without polymerthe HORSEPOWER prospective and multicentre study.BackgroundDelayed endothelial coverage of stent struts has been linked to stent thrombosis, especially after drug-eluting stent (DES) implantation. The absence of polymer in DES systems may induce earlier strut coverage and thereafter reduce the occurrence of stent thrombosis. Shorter periods of dual antiplatelet therapy would be then accepted to reduce bleeding in those patients at high risk.AimTo assess the healing characteristics among different DES at 1 and 6 months after stent implantation and in different clinical presentations by optical coherence tomographic (OCT).MethodsThe HORSEPOWER trial is a prospective, multi-center study evaluating vascular healing patterns with OCT at 1 and 6 months after stent implantation. A total 55 patients with de novo similar coronary lesions treated with polymer-free Biolimus A9 (BA9) stent, everolimus-eluting stent with abluminal bioabsorbable polymer (EESb) and everolimus-eluting stent with persistent polymer (EESp) underwent examination with OCT. Blinded analysis was done at a central core lab. Co-primary endpoints were proportion of struts with coverage and with apposition at 1 and 6 months among the three different stents and clinical presentation (ACS vs stable coronary disease).ResultsAll stents were successfully implanted in all patients, without per-procedural complications. There were no significant differences between groups regarding clinical, angiographic measurements, and procedural data. The rate of uncovered and malapposed struts decreased over time (p