Abstract 14895: Bicuspid Aortic Valves Facilitate Significantly Increased 3-Dimensional Pressure Gradients, Circumferential Wall Shear Stress, and Viscous Energy Loss

IntroductionBy investigating the concomitance of altered 3D pressure gradients (3D-PG), wall shear stress (WSS), and viscous energy loss (EL) in bicuspid aortic valve (BAV) patients, a more holistic understanding of recondite BAV hemodynamic parameters is achieved.HypothesisAortic 3D-PG, WSS, and EL will be significantly greater in BAV patients than healthy controls.MethodsTwelve healthy controls (28±12 years, 6 female) and 37 BAV patients (44±14 years, 10 female) underwent cardiac MRI at 3T, inclusive of cine imaging and 4D flow. Nine cross sections (Figure 1) were placed along aortas in distinct locationsleft ventricular outflow tract (LVOT), sinus of Valsalva (SOV), sinotubular junction (STJ), mid-ascending aorta (MAA), proximal to first branch (AA1), between second and third branches (AA2), distal to third branch (AA3), proximal descending aorta (PDA), and distal descending aorta (DDA). Cross sections were analyzed for (i) 3D-PG (reported as deviance from corresponding LVOT value), (ii) net flow, (iii) peak velocity, (iv) regurgitation, and (v) WSS. Energy loss (from LVOT to AA1) and pulse wave velocity were also calculated.ResultsSignificant findings shown in Table 1. In addition, strong correlations were found between (i) average EL and MAA circumferential WSS (R=0.701, p