Abstract 14381: The Novel Paclitaxel-Eluting Biodegradable Peripheral Igaki-Tamai Stent: Optical Coherence Tomography and Histology in a Pre-Clinical Porcine Iliac Artery Model
IntroductionThe peripheral Igaki-Tamai stent (Kyoto Medical Planning Co, Ltd, Kyoto, Japan) is the only biodegradable scaffold which has been used commercially for the treatment of peripheral arteries in Europe since 2009. Though this biodegradable scaffold may overcome long-term limitations of the...
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Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A14381-A14381 |
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Zusammenfassung: | IntroductionThe peripheral Igaki-Tamai stent (Kyoto Medical Planning Co, Ltd, Kyoto, Japan) is the only biodegradable scaffold which has been used commercially for the treatment of peripheral arteries in Europe since 2009. Though this biodegradable scaffold may overcome long-term limitations of the metallic stents, a concern for restenosis still exists due to its non-drug eluting property. The novel paclitaxel-eluting Igaki-Tamai stent has the same backbone structure of Igaki-Tamai stent coated with a matrix of biodegradable PLLA polymer and paclitaxel. This study sought to evaluate the difference in neointimal and inflammatory responses between these two scaffolds by optical coherence tomography (OCT) and histology in a porcine iliac artery model.MethodsIn total, 4 non-drug eluting peripheral Igaki-Tamai stent (bare Igaki-Tamai stent, 7.0х36mm), and 4 paclitaxel-eluting peripheral Igaki-Tamai stent (PTX Igaki-Tamai stent, 7.0х36mm) were implanted in porcine iliac arteries. All the swine underwent serial OCT follow-up at 1 month, and 3 months. Cross-sectional OCT images were analyzed at 1 mm longitudinal intervals. A total of 530 OCT cross-sections were analyzed. Histological evaluation (bare Igaki-Tamai stent n=3, PTX Igaki-Tamai stent n=4) was performed following euthanasia after OCT follow-up at 3 months. A total of 21 cross-sections and 278 struts were analyzed histologically.ResultsBy OCT analysis, percentage area stenosis was significantly lower in the PTX Igaki-Tamai stent than in the bare Igaki-Tamai stent both at 1 month (17.8% vs 34.9%; p=0.03) and 3 months (27.7% vs 41.4%; p=0.03). Histological evaluation revealed low-grade inflammation in both scaffolds.ConclusionsIn this pre-clinical porcine iliac artery model, PTX Igaki-Tamai stent revealed significantly lower neointimal response up to 3 months than bare Igaki-Tamai stent with no evidence of significant inflammatory response. |
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ISSN: | 0009-7322 1524-4539 |