Abstract 12996: Differences of Vascular Healing After Percutaneous Coronary Intervention Between Biodegradable-Polymer and Durable-Polymer New Generation Everolimus-Eluting Stents: An Optical Coherence Tomography Analysis

IntroductionWhether biodegradable-polymer drug-eluting stents (BP-DES) can induce a more favorable vascular response at follow-up than durable-polymer drug-eluting stents (DP-DES) remains controversial. Thus, we evaluate the differences of the vascular response after percutaneous coronary intervention (PCI) between biodegradable-polymer everolimus-eluting stents (BP-EES) and durable-polymer everolimus-eluting stents (DP-EES) which have same drug and similar strut thickness by optical coherence tomography (OCT) imaging.MethodsWe enrolled the consecutive patients who underwent PCI with BP-EES or DP-EES and 8-month follow-up coronary angiogram and OCT from August 2016 to September 2017. We compared the OCT parameters including percentage of covered struts, uncovered struts, well-apposed and uncovered struts and malapposed struts, and mean neointimal hyperplasia (NIH) thickness between BP-EES and DP-EES.ResultsBP-EES consisted of 19 lesions and DP-EES consisted of 24 lesions. A total of 239 frames with 1,740 struts in BP-EES and 257 frames with 2,159 struts in DP-EES were analyzed. As shown in a table, the percentage of malapposed struts was significantly lower with BP-EES than DP-EES (0.2±0.4% and 2.3±4.9%, p=0.023), whereas the other OCT parameters were not significantly different between BP-EES and DP-EES.ConclusionsThe present OCT study demonstrated that incomplete vascular healing characterized by the presence of malapposed struts was less common in BP-EES compared with DP-EES. Biodegradable-polymer may be more favorable than durable-polymer in EES from the point of view of vascular healing.