Abstract 12658: Quantifying the Impact of Influenza on Cardiovascular Health Outcomes and Activity Among Persons With Type 2 Diabetes Mellitus

IntroductionDiabetes independently increases the risks of poor outcomes from influenza and cardiovascular disease, yet the short term impact of influenza infection on daily activities and cardiovascular outcomes for persons with Type-2 Diabetes Mellitus remains sub-optimally described.MethodsPopulation based self-control case design of adults (age ≥ 18) from a large US health plan of Type 2 Diabetes Mellitus and age and gender matched non-diabetic controls. Moreover, we compared the per-individual influenza period (2 weeks before and 4 weeks after an incident influenza diagnosis) to the 6-week preceding baseline period. The health plan offers a digital platform connecting consumer wearable devices for tracking activities such as steps and sleep as well as heart rate data. Medical and pharmacy claims data was used to define cohorts, medically attended influenza events, and measure medical outcomes. Digital tracking data was aggregated at minute-, day-, week- and year-level time slices for analysis.Results54,656 patients with Type 2 Diabetes and 113,016 non-diabetic controls comprised the initial cohort. In the influenza period, people with diabetes had more incident diagnoses of ischemic heart disease and hypertension compared to controls (8.36 and 2.56 n-fold increase respectively, p