Abstract 18657: Impaired Peripheral Endothelial Function Assessed by Digital Reactive Hyperemia Peripheral Arterial Tonometry and Risk of In-Stent Restenosis

IntroductionDrug-eluting stents (DES) are replacing bare-metal stents (BMS), but in-stent restenosis (ISR) remains a problem. Impaired endothelial function is a key event in the atherosclerosis process and a predictor of future cardiovascular events. Reactive hyperemia index (RHI) assessed by peripheral arterial tonometry evaluates endothelial function noninvasively.HypothesisWe prospectively assessed the prognostic value of RHI in predicting ISR after percutaneous coronary intervention (PCI).MethodsRHI was measured before PCI and at follow-up (F/U) angiography (6 and 9 months post BMS- and DES-PCI, respectively) in 249 consecutive patients. ISR was defined as >50% stenosis at F/U assessed by quantitative coronary angiography.ResultsISR was seen in 68 patients (27.3%). F/U ln(RHI) was significantly lower in patients with ISR than in those without (0.52 ± 0.23 vs. 0.65 ± 0.27, p