Abstract 18503: Relationship Between Left Ventricular Fibrosis and Abnormalities of Mitral Annulus in Arrhythmic Mitral Valve Prolapse

IntroductionMitral valve prolapse (MVP) is characterized by myxomatous leaflets and in those subjects with malignant ventricular arrhythmias the presence of myocardial fibrosis at the level left ventricular inferobasal wall and papillary muscles have been recently demonstrated.HypothesisWe investiga...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A18503-A18503
Hauptverfasser:	Perazzolo Marra, Martina, Basso, Cristina, De Lazzari, Manuel, Rizzo, Stefania, Cipriani, Alberto, Giorgi, Benedetta, Lacognata, Carmelo, Rigato, Ilaria, Migliore, Federico, Pilichou, Kalliopi, Cacciavillani, Luisa, Bertaglia, Emanuele, Frigo, Anna Chiara, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Iliceto, Sabino
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	IntroductionMitral valve prolapse (MVP) is characterized by myxomatous leaflets and in those subjects with malignant ventricular arrhythmias the presence of myocardial fibrosis at the level left ventricular inferobasal wall and papillary muscles have been recently demonstrated.HypothesisWe investigated the role of morpho-functional abnormalities of the mitral valve that could explain a regional mechanical myocardial stretch.Methods and ResultsThirty-seven (28 females; median age 43 years) arrhythmic MVP patients with LV late-gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) and no or trivial mitral regurgitation and 18 (7 females; median age 40 years) MVP patients without LGE were investigated by morpho-functional CMR. Mitral annulus disjunction (MAD, median 4.9 mm vs. 0.8, p
ISSN:	0009-7322 1524-4539