Abstract 18267: Does High Triglycerides/High-Density Lipoprotein Cholesterol Ratio Predict Outcomes in an Australian Population of Patients After Coronary Angiography?

AimsHigh Triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) are major cardiovascular risk factors. A positive association between elevated TG/HDL-C ratio and all-cause mortality and major adverse cardiovascular events (MACEs) have been reported. However, if high TG/HDL-C ratio can predict outcomes in an Australian population of patients after coronary angiography, has not been reported.MethodsBaseline biochemistry, detailed demographic and clinical data had been obtained from 850 patients at the time of enrolment into the study. Follow-up information was collected using a questionnaire by contacting patients. Subjects were stratified into two groups of TG/HDL-C ratio by dividing the baseline TG/HDL-C ratio at 2.5. Multivariate cox-proportional hazard models were constructed for all-cause mortality over a median follow-up period of 5.5 years, using TG/HDL-C ratio as a predictor variable and analysing for cardiovascular risk factors. A multivariate logistic regression model for MACEs was constructed to analyse if TG/HDL-C ratio is a risk factor.ResultsFollow up information was obtained from 522 subjects. 482 subjects had baseline TG/HDL-C ratio and were included in the final data analysis. The subjects mean age was 63.4±11 years, 69% were Males, 74.7% were hypertensive, 80.6% had hypercholesterolemia, 29.6% were diabetic, 70.8% had Coronary Artery Disease (CAD) and 68.7% were either active or previous smokers. Baseline TG/HDL- C ratio ranged from 0.21 to 7.73. During the follow-up period, there were 49 deaths. In a multivariate Cox-proportional hazard model after adjusting for gender, age, smoke and history of diabetes, hypertension and hypercholesterolemia, subjects who had a baseline TG/HDL-C ratio ≥2.5 had a 3-fold increased risk of mortality compared to subjects who had a baseline TG/HDL-C ratio ≤2.5. In a multivariate regression model, after adjusting for conventional cardiovascular risk factors, TG/HDL-C ratio was not significantly associated with MACEs.ConclusionTG/HDL-C ratio ≥2.5 is a powerful independent predictor of all-cause mortality in this population of patients after coronary angiography. However, TG/HDL-C ratio is not a powerful independent risk factor for MACEs in this study cohort.