Abstract 17694: Evaluation of Myocardial Stiffness Change Over Age in Healthy Adult and Hypertrophic Cardiomyopathy Populations Using New Noninvasive Ultrasound Shear Wave Imaging

ObjectivesGenerated ultrasound shear wave velocity through the myocardium has been validated to be correlated to the shear modulus of the myocardium and therefore to the intrinsic myocardial stiffness (MS, kPa). The goal of our study was to investigate the potential of Myocardial Shear Wave Imaging, to quantify noninvasively the age change of passive diastolic myocardial stiffness in healthy population and its variation vs. hypertrophic cardiomyopathy (HCM) adult populations.MethodsWe included prospectively 40 adults30 healthy volunteer (divided into three groups20-40 yo (n=10); 40-60 yo (n=10); 60-80 yo (n=10)) and 10 HCM. A complete echocardiography and cardiac magnetic resonance imaging (MRI) were as well achieved in all the study population. MS was evaluated using an ultrafast ultrasound system (Aixplorer, Supersonic Imagine, France) and a phased-array probe (2.75 MHz). The MS estimation was performed on the basal antero-septal segment during the end of the diastole with ECG triggering, in a short axis (SA) and long axis (LA) views. MS were compared between the different groups and analyzed with the clinical parameters of echocardiography and MRI.ResultsFor 20-40, 40-60, and 60-80 yo group respectively, the mean SA-MS was 1.21±0.26 kPa, 1.83±0.51 kPa, 2,96±0.44 kPa and the mean LA-MS was 0.74±0.11 kPa, 1.17±0.18 kPa, 1.98±0.53 kPa. MS significantly correlated with age (r=0.75, p