Abstract 17054: Genes Associated With Inotrope Requirements in Children Undergoing Tetralogy of Fallot Repair

IntroductionInotropes are used to prevent or treat postoperative low cardiac output syndrome. Common variants in adrenergic (ADR) signaling genes can influence inotrope response. We investigated association of both common and rare variants in ADR signaling genes with inotrope requirements in tetralogy of Fallot (TOF) patients undergoing surgical repair.MethodsOf 276 TOF eligible patients, 120 with complete 72 hour post-operative data were analyzed. All common and rare (48hrs, doubling of dose, or initiation of additional inotrope). Mean CPB time was higher in the high-inotrope vs low inotrope group (128±58 vs 100±34 mins, p =0.002), as was ACC time (88±35 vs 76±25 mins, p=0.038). After adjusting for CPB and ACC time, high inotrope group had lower 24 hour mean blood pressures (p