Use of Bi-Allelic Insertion/Deletion Polymorphisms as a Positive Control for Fetal Genotyping in Maternal Blood

Use of Bi-Allelic Insertion/Deletion Polymorphisms as a Positive Control for Fetal Genotyping in Maternal Blood

:  Amplification of fetal DNA in maternal plasma is a new way for non‐invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi‐allelic highly polymorphic markers t...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2006-09, Vol.1075 (1), p.123-129
Hauptverfasser: PAGE-CHRISTIAENS, GODELIEVE C.M.L., BOSSERS, BERNADETTE, VAN DER SCHOOT, C. ELLEN, DE HAAS, MASJA
Format: Artikel
Sprache:eng
Schlagworte:
bi-allelic polymorphisms
fetal DNA
maternal plasma
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Zusammenfassung::  Amplification of fetal DNA in maternal plasma is a new way for non‐invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi‐allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal “disease” sequence.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1368.016