Gallic acid protects against Aflatoxin B1‐induced oxidative and inflammatory stress damage in rats kidneys and liver

Gallic acid protects against Aflatoxin B1‐induced oxidative and inflammatory stress damage in rats kidneys and liver

The adverse effect of Aflatoxin B1 (AFB1) exposure in both humans and rodents has been widely reported. The beneficial health effects of gallic acid (GA) against AFB1‐induced toxicity in vitro have been published. Here, we present in vivo findings on AFB1 and GA on hepatorenal function in rats, expo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of food biochemistry 2020-08, Vol.44 (8), p.n/a
Hauptverfasser: Owumi, Solomon, Najophe, Eseroghene S., Farombi, Ebenezer O., Oyelere, Adegboyega K.
Format: Artikel
Sprache:eng
Schlagworte:
Aflatoxin B1
gallic acid
hepatorenal toxicity
inflammatory markers
oxidative stress
rats
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The adverse effect of Aflatoxin B1 (AFB1) exposure in both humans and rodents has been widely reported. The beneficial health effects of gallic acid (GA) against AFB1‐induced toxicity in vitro have been published. Here, we present in vivo findings on AFB1 and GA on hepatorenal function in rats, exposed to AFB1 (75 µg/kg body weight) only or co‐treated with GA (20 or 40 mg/kg) for 28 successive days. AFB1 significantly increased pro‐inflammatory biomarkers and suppressed IL‐10 levels in rats’ liver and kidney. AFB1 caused increased (p 
ISSN:0145-8884
1745-4514
DOI:10.1111/jfbc.13316