Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis

Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis

Objectives: To assess the short‐ and long‐term efficacy of proton pump inhibitor (PPI) therapy for pediatric eosinophilic esophagitis (EoE) in real‐world practice with a step‐down strategy, and to evaluate factors predictive of PPI responsiveness. Methods: We collected data regarding the efficacy of...

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Veröffentlicht in:Journal of pediatric gastroenterology and nutrition 2023-02, Vol.76 (2), p.191-198
Hauptverfasser: Gutiérrez‐Junquera, Carolina, Fernández‐Fernández, Sonia, Domínguez‐Ortega, Gloria, Vila Miravet, Víctor, García‐Puig, Roger, La Orden‐Izquierdo, Enrique, Peña Quintana, Luis, Barrio Torres, Josefa, Medina Benítez, Enrique, Leis, Rosaura, García‐Romero, Ruth, Fernández de Valderrama, Ana, Vecino López, Raquel, Donado Palencia, Paloma, Beltrán, Marina Alvarez, Reyes‐Domínguez, Ana Isabel, Colomé‐Rivero, Gemma, Manchón, Silvia Rodríguez, Martinón, Nazareth, Fernández‐Caamaño, Beatriz, Garrido, Helena Lorenzo, Comas, Amadeu Roca, Riechmann, Enriqueta Román, Pascual, Maria Luz Cilleruelo, Tellería, Pedro Urruzuno, Arocena, Francisco Javier Eizaguirre, Serrano, Elena Balmaseda, García, Patricia Barros, Arnal, Ignacio Ros, García, Gloria Rodrigo, Díaz, Anabel Ruiz, Poblet, Gonzalo Galicia, Barreda, Laura, Querol, Montserrat Montraveta, Vicente, Carmen Alonso, Santamaria, Saioa Vicente, Jaime, Beatriz Espín, Peral, Ricardo Torres, Peris, Mónica García, Vegas Álvarez, Ana Maria, Blazquez, Cristina Iglesias
Format: Artikel
Sprache:eng
Schlagworte:
adverse events
children
eosinophilic esophagitis
histological remission
registry
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Zusammenfassung:Objectives: To assess the short‐ and long‐term efficacy of proton pump inhibitor (PPI) therapy for pediatric eosinophilic esophagitis (EoE) in real‐world practice with a step‐down strategy, and to evaluate factors predictive of PPI responsiveness. Methods: We collected data regarding the efficacy of PPIs during this cross‐sectional analysis of the prospective nationwide RENESE registry. Children with EoE treated with PPI monotherapy were included. Histological remission was defined as a peak eosinophilic count of
ISSN:0277-2116
1536-4801
DOI:10.1097/MPG.0000000000003660