Parenteral Zinc Intake in Newborns With Jejunostomy or Ileostomy
ABSTRACT Objectives: The aim of the study was to assess zinc status of newborns with parenteral nutrition with or without a small bowel stoma, to determine the incidence of zinc deficit, and to determine the clinical factors associated with plasma zinc levels. Methods: Monocentric cohort study inclu...
Gespeichert in:
Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2020-04, Vol.70 (4), p.521-526 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | ABSTRACT
Objectives:
The aim of the study was to assess zinc status of newborns with parenteral nutrition with or without a small bowel stoma, to determine the incidence of zinc deficit, and to determine the clinical factors associated with plasma zinc levels.
Methods:
Monocentric cohort study including all liveborn infants receiving zinc parenteral intake at 500 μg · kg−1 · day−1 and who benefited from at least 1 plasma zinc assessment during hospitalization.
Results:
Sixty‐eight dosages of zinc were performed in 50 newborns, divided into 3 groups (no stoma = 26, jejunostomy = 11, ileostomy = 13). Thirty‐seven of the 50 infants were born preterm. The mean ± standard deviation plasma zinc was 14.9 ± 4.3 μmol/L and was similar among the 3 groups. Sixty‐four percent, 3%, and 34% of zinc values were within, below, and above the normal range, respectively. In infants with jejunostomy, only 1 plasma zinc value (5%) was below the reference range. Plasma zinc levels were negatively correlated with stoma output (r2 = −0.449; P = 0.013). In contrast to patients with limited intestinal losses (ie, no stoma and ileostomy groups) no association between zinc levels and postmenstrual age was observed in infants with a jejunostomy suggesting that 500 μg · kg−1 · day−1 was adequate not only in preterm infants but also in term infants with a jejunostomy.
Conclusion:
Plasma zinc levels decrease significantly with the increase of stoma output volume of newborns with small bowel stoma. Zinc deficit was prevented in newborns with a small bowel stoma receiving of 500 μg · kg−1 · day−1 of parenteral zinc. |
---|---|
ISSN: | 0277-2116 1536-4801 |
DOI: | 10.1097/MPG.0000000000002596 |