Cover Feature: Electrochemical Installation of CFH2−, CF2H−, CF3−, and Perfluoroalkyl Groups into Small Organic Molecules (Chem. Rec. 9/2021)

Cover Feature: Electrochemical Installation of CFH2−, CF2H−, CF3−, and Perfluoroalkyl Groups into Small Organic Molecules (Chem. Rec. 9/2021)

The cover picture displays fluoroalkyl radicals as reactive intermediates in the electrochemical (per)fluoroalkylation and representative examples of electrochemically fluoroalkylated small molecules. The installation of fluoroalkyl moieties into drug candidates significantly promotes their potency....

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Veröffentlicht in:Chemical record 2021-09, Vol.21 (9), p.2078-2078
Hauptverfasser: Kisukuri, Camila M., Fernandes, Vitor A., Delgado, José A. C., Häring, Andreas P., Paixão, Márcio W., Waldvogel, Siegfried R.
Format: Artikel
Sprache:eng
Schlagworte:
difluoromethylation
electrosynthesis
fluoromethylation
perfluoroalkylation
trifluoromethylation
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Zusammenfassung:The cover picture displays fluoroalkyl radicals as reactive intermediates in the electrochemical (per)fluoroalkylation and representative examples of electrochemically fluoroalkylated small molecules. The installation of fluoroalkyl moieties into drug candidates significantly promotes their potency. Electrosynthesis is a sustainable and powerful technology to tackle this challenging synthetic task. Consequently, electrochemical fluoroalkylation of small organic molecules has become a vivid area of research, which is surveyed by S. R. Waldvogel and co‐workers in their Record Review (DOI: 10.1002/tcr.202100065).
ISSN:1527-8999
1528-0691
DOI:10.1002/tcr.202180905